6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although the underlying cause of Huntington's disease (HD) is well established, the actual pathophysiological processes involved remain to be fully elucidated. In other proteinopathies such as Alzheimer's and Parkinson's diseases, there is evidence for impairments of the cerebral vasculature as well as the blood-brain barrier (BBB), which have been suggested to contribute to their pathophysiology. We investigated whether similar changes are also present in HD.

          Related collections

          Author and article information

          Journal
          Ann. Neurol.
          Annals of neurology
          1531-8249
          0364-5134
          Aug 2015
          : 78
          : 2
          Affiliations
          [1 ] Department of Clinical Neurosciences, John van Geest Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom.
          [2 ] Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
          [3 ] Centre de recherche du CHU de Québec (CHUQ), Québec, Québec, Canada.
          [4 ] Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom.
          [5 ] Faculté de Pharmacie, Université Laval, Québec, Québec, Canada.
          [6 ] Département de Médecine Moléculaire, Université Laval, Québec, Québec, Canada.
          [7 ] Département de Psychiatrie & Neurosciences, Université Laval, Québec, Québec, Canada.
          Article
          10.1002/ana.24406
          25866151
          960330dd-53ca-4046-b53c-2f37573dd2d9
          © 2015 American Neurological Association.
          History

          Comments

          Comment on this article