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      Association between the ERCC1 polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer: a meta-analysis

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          Abstract

          Background

          Ovarian cancer is a prominent public health problem which affects people all around the world. Platinum-based chemotherapy is a common treatment for ovarian cancer, however, the effectiveness of chemotherapy varies from patient to patient. The excision repair cross complementation group 1 (ERCC1) protein may mediate chemotherapy resistance. A meta-analysis was conducted to explore whether platinum-based chemotherapy effectiveness could be attributed to the ERCC1 C19007T polymorphisms.

          Methods

          Seven major databases (EMBASE, Web of Science, Pubmed, Springer Link, Chinese National Knowledge Infrastructure (CNKI), EBSCO and Science Direct databases) were searched for eligible studies. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the results.

          Results

          In this meta-analysis, 1169 subjects (425 non-responders and 744 responders) from 8 studies were included. The overall OR (C vs. T alleles) using random model was 1.07 (95% CI 0.75-1.52, P = 0.7), which was not statistically significant. Moreover, there was no significant difference in the analysis by race.

          Conclusion

          There is no association between the ERCC1 C19007T polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer. The polymorphism did not have a significant impact on platinum-based chemotherapy in non-responders and responders.

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          Most cited references17

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          Publication bias and dissemination of clinical research.

          A. Begg, J Berlin (1989)
          Publication bias is a widely recognized phenomenon that occurs because of the influence of study results on the chances of publication. Usually, studies with positive results are more likely to be published than studies with negative results, which leads to a preponderance of false-positive results in the literature. Empiric studies have demonstrated that the induced bias is large and can have a serious impact on meta-analyses, in which data from several studies are aggregated, as well as on informal reviews. The problem is deeply embedded in current research practice, which encourages demonstration of statistical significance to "prove" theories, and one of its causes is the pressure to publish extensively that is an integral part of the competition for academic promotion. Serious efforts to reduce this problem will involve restructuring the process by which study results are disseminated, changing editorial policies, and altering the style and methods of statistical analysis.
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            Current status of excision repair cross complementing-group 1 (ERCC1) in cancer.

            Srinivasan Madhusudan, Lucy Gossage (2007)
            Cisplatin, carboplatin and oxaliplatin are some of the most widely used anti-cancer agents in solid tumours. The cytotoxicity of platinating agents is directly related to their ability to cause DNA intra-strand crosslinks that trigger a series of intracellular events that ultimately result in cell death. DNA intra-strand crosslinks are processed and repaired by the nucleotide excision repair pathway. It is now clear that nucleotide excision repair (NER) capacity may have a major impact on the emergence of resistance, normal tissue tolerance and patient outcomes. ERCC1 is a key player in NER. In this review, we provide an overview of mammalian NER and then focus on biochemical, structural and pre-clinical aspects of ERCC1. We then present current clinical evidence implicating ERCC1 as a predictive and prognostic marker in cancer. Early evidence also suggests that ERCC1 or the pathways involved in the regulation of ERCC1 expression may be attractive anti-cancer targets. Such agents are expected to potentiate the cytotoxicity of platinating agents and could have a major impact on cancer therapy.
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              Curing metastatic cancer: lessons from testicular germ-cell tumours.

              John Masters, Beate Köberle (2003)
              Most metastatic cancers are fatal. More than 80% of patients with metastatic testicular germ-cell tumours (TGCTs), however, can be cured using cisplatin-based combination chemotherapy. Why are TGCTs more sensitive to chemotherapeutics than most other tumour types? Answers to this question could lead to new treatments for metastatic cancers.
              Article 0 comments Cited 41 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Ning Tang: tangningdr@gmail.com
                Dan Lyu: lvdan918@163.com
                Yan Zhang: zhangyan92363@163.com
                Haiping Liu:
                ORCID: http://orcid.org/0000-0001-7976-9151
                +86-13791131463 , haipingliu2010@outlook.com
                Journal
                Journal ID (nlm-ta): BMC Womens Health
                Journal ID (iso-abbrev): BMC Womens Health
                Title: BMC Women's Health
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1472-6874
                Publication date (Electronic): 17 June 2017
                Publication date PMC-release: 17 June 2017
                Publication date Collection: 2017
                Volume: 17
                Electronic Location Identifier: 43
                Affiliations
                [1 ]GRID grid.452547.5, Reproductive Medicine Center, , Jinan Military General Hospital, ; 25 Shifan Road, Tianqiao District, Jinan, Shandong Province 250031 China
                [2 ]ISNI 0000 0004 0605 6814, GRID grid.417024.4, Department of Pain, , Tianjin First Center Hospital, ; Nankai District, Tianjin, 300192 China
                Author information
                http://orcid.org/0000-0001-7976-9151
                Article
                Publisher ID: 393
                DOI: 10.1186/s12905-017-0393-z
                PMC ID: 5474010
                PubMed ID: 28623887
                SO-VID: 9611eb91-a593-409c-8250-4dd6f258bf12
                Copyright © © The Author(s). 2017
                License:

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 11 September 2015
                Date accepted : 16 May 2017
                Funding
                Funded by: President Funding of Jinan Military General Hospital
                Award ID: No. 2012Q005
                Funded by: PLA General Logistics Department of the Ministry of Health
                Award ID: 13QNP030
                Categories
                Subject: Research Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2017

                ScienceOpen disciplines: Obstetrics & Gynecology
                Keywords: ercc1 c19007t,platinum-based chemotherapy,ovarian cancer
                Data availability:
                ScienceOpen disciplines: Obstetrics & Gynecology
                Keywords: ercc1 c19007t, platinum-based chemotherapy, ovarian cancer

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