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      Naloxone Prevents Dark-Background Adaptation in Amphibians

      ,

      Neuroendocrinology

      S. Karger AG

      Naloxone, Melanocyte-stimulating hormone, Amphibians

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          Abstract

          Pituitary intermediate lobe melanocyte-stimulating hormone (MSH) is responsible for normal skin darkening in amphibians. Light-background adapted frogs ( Rana pipiens) injected with naloxone and placed on black backgrounds maintain melanophore indices and pituitary cytology characteristic of light-background adaptation. In vitro and in vivo experiments showed that naloxone hydrochloride did not have a direct effect on skin melanophores or on the neurointer-mediate lobe. These data suggest that naloxone acts at the level of the central nervous system to inhibit the mechanism(s) responsible for release of MSH when light-background adapted frogs are placed on a dark background. Release of MSH, known to be tonically inhibited by the hypothalamus, may be modulated by opiate receptor-dependent mechanisms.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1980
          1980
          26 March 2008
          : 31
          : 6
          : 385-389
          Affiliations
          Department of Anatomy, University of New Mexico, School of Medicine, Albuquerque, N. Mex. USA
          Article
          123108 Neuroendocrinology 1980;31:385–389
          10.1159/000123108
          6969864
          © 1980 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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