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      The hypoxia signaling pathway and hypoxic adaptation in fishes.

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      Science China. Life sciences

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          Abstract

          The hypoxia signaling pathway is an evolutionarily conserved cellular signaling pathway present in animals ranging from Caenorhabditis elegans to mammals. The pathway is crucial for oxygen homeostasis maintenance. Hypoxia-inducible factors (HIF-1α and HIF-2α) are master regulators in the hypoxia signaling pathway. Oxygen concentrations vary a lot in the aquatic environment. To deal with this, fishes have adapted and developed varying strategies for living in hypoxic conditions. Investigations into the strategies and mechanisms of hypoxia adaptation in fishes will allow us to understand fish speciation and breed hypoxia-tolerant fish species/strains. This review summarizes the process of the hypoxia signaling pathway and its regulation, as well as the mechanism of hypoxia adaptation in fishes.

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          Author and article information

          Journal
          Sci China Life Sci
          Science China. Life sciences
          1869-1889
          1674-7305
          Feb 2015
          : 58
          : 2
          Affiliations
          [1 ] Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China, w-xiao@ihb.ac.cn.
          Article
          10.1007/s11427-015-4801-z
          25595051
          96472b9e-8bef-483c-99ee-578f7790da3b
          History

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