Ilker Inanc Balkan , Ayse Batirel 1 , Oguz Karabay 2 , Canan Agalar 3 , Serife Akalin 4 , Ozlem Alici 3 , Emine Alp 5 , Fatma Aybala Altay 6 , Nilgun Altin 7 , Ferhat Arslan 8 , Turan Aslan 9 , Nural Bekiroglu 10 , Salih Cesur 7 , Aygul Dogan Celik 11 , Mustafa Dogan 12 , Bulent Durdu 13 , Fazilet Duygu 14 , Aynur Engin 15 , Derya Ozturk Engin 16 , Ibak Gonen 17 , Ertugrul Guclu 2 , Tumer Guven 18 , Cigdem Ataman Hatipoglu 19 , Salih Hosoglu 20 , Mustafa Kasim Karahocagil 21 , Aysegul Ulu Kilic 5 , Bahar Ormen 22 , Davut Ozdemir 23 , Serdar Ozer 1 , Nefise Oztoprak 24 , Nurbanu Sezak 23 , Vedat Turhan 25 , Nesrin Turker 23 , Hava Yilmaz 26
To compare the efficacy of colistin (COL) monotherapy versus non-COL based combinations in the treatment of bloodstream infections (BSIs) due to multidrug resistant Acinetobacter spp.(MDR-A).
Retrospective data of 107 MDR-A BSI cases from 27 tertiary centers in Turkey were included.
Thirty-six patients in the COL monotherapy (CM) group and 71 in the non-COL based combinations (NCC) group were included in the study. Mean age was 59.98 ± 20 years (range: 18–89) and 50.5% were male. Median duration of follow-up was 40 days (range: 9–297). The 14-day survival rates were 52.8% in CM and 47.23% in NCC group ( P = 0.36). Microbiological eradication was achieved in 69% of CM and 83% of NCC group ( P = 0.13). Treatment failure was detected in 22.9% of cases in both CM and NCC groups. Univariate analysis revealed that mean age ( P = 0.001), Charlson comorbidity index ( P = 0.03), duration of hospital stay before MDR-A BSI ( P = 0.04), Pitt bacteremia score ( P = 0.043) and Acute Physiology and Chronic Health Evaluation II score ( P = 0.05) were significant in terms of 14-day mortality. Advanced age ( P = 0.01) and duration of hospital stay before MDR-A BSI ( P = 0.04) were independently associated with 14-day mortality in multivariate analysis.