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      Age-Related Changes in Plasma Dehydroepiandrosterone Sulphate, Cortisol, Testosterone and Free Testosterone Circadian Rhythms in Adult Men

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          Abstract

          The circadian rhythms of serum luteinizing hormone, follicle-stimulating hormone, testosterone (T), free testosterone (fT), sex hormone-binding globulin (SHBG), oestradiol, cortisol and dehydroepiandrosterone sulphate (DHA-s) have been investigated in 5 normal male adults and 6 elderly men. Circadian rhythms were detected statistically significant (p < 0.05) by population mean cosinor analysis, for T, fT, cortisol and DHA-s in the young group. In the elderly population, serum cortisol showed a clear circadian rhythm, although with some phase modification, whereas DHA-s secretion lost its circadian rhythmicity. This demonstrates that ageing differently affects the two major adrenal functions, glucocorticoid and androgenic; further, the data suggest that an independent adrenal androgen-regulating system could be selectively impaired in the older subjects. In the elderly group the loss of T circadian rhythm was confirmed, but a statistically significant circadian rhythm of fT was recorded. It was characterized by a marked phase advance and not related with the SHBG modifications found in elderly men. This finding leads us to reconsider the role of fT, which appears more sensitive than total T, in studying circadian rhythm of gonadal androgen secretion.

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          Author and article information

          Journal
          HRE
          10.1159/issn.0018-5051
          Hormone Research in Paediatrics
          S. Karger AG
          0018-5051
          2571-6603
          1988
          1988
          28 November 2008
          : 29
          : 1
          : 1-6
          Affiliations
          Department of Endocrinology, Centre of Chronoendocrinology, University of Modena, Italy
          Article
          180956 Horm Res 1988;29:1–6
          10.1159/000180956
          © 1988 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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