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      Epithelial-mesenchymal transitions in development and disease.

      1 , , ,
      Cell
      Elsevier BV

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          Abstract

          The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          1097-4172
          0092-8674
          Nov 25 2009
          : 139
          : 5
          Affiliations
          [1 ] IMCB, A*STAR, Proteos, Singapore 138673, Republic of Singapore. jpthiery@imcb.a-star.edu.sg
          Article
          S0092-8674(09)01419-6
          10.1016/j.cell.2009.11.007
          19945376
          966f8852-6fb0-4284-a400-9ae2fa896eb6
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