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      Synonymous but not the same: the causes and consequences of codon bias.

      Nature reviews. Genetics

      Animals, Protein Biosynthesis, Mutation, Mice, Humans, Genome, Gene Expression, genetics, Drosophila Proteins, Codon

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          Abstract

          Despite their name, synonymous mutations have significant consequences for cellular processes in all taxa. As a result, an understanding of codon bias is central to fields as diverse as molecular evolution and biotechnology. Although recent advances in sequencing and synthetic biology have helped to resolve longstanding questions about codon bias, they have also uncovered striking patterns that suggest new hypotheses about protein synthesis. Ongoing work to quantify the dynamics of initiation and elongation is as important for understanding natural synonymous variation as it is for designing transgenes in applied contexts.

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          Author and article information

          Journal
          21102527
          3074964
          10.1038/nrg2899

          Chemistry

          Animals, Protein Biosynthesis, Mutation, Mice, Humans, Genome, Gene Expression, genetics, Drosophila Proteins, Codon

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