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      Changes in the anterior segment after cycloplegia with a biometer using swept-source optical coherence tomography

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          Abstract

          The aim of this study was to investigate changes in the anterior segment of the eye after cycloplegia. A biometer combined with swept-source optical coherence tomography (SSOCT) was used for measurements. Patients with strabismus or amblyopia who underwent cycloplegia were included. The axial length, central corneal thickness, anterior chamber depth, and lens thickness were measured with the biometer–SSOCT system before and after cycloplegia. Altogether, 10 eyes of 10 patients (mean age 7.20 ± 3.08 years, range 4–14 years) were evaluated. The mean measurements before cycloplegia were 22.75 ± 0.96 mm axial length, 516 ± 33 μm central corneal thickness, 3.40 ± 0.21 mm anterior chamber depth, and 3.77 ± 0.26 mm lens thickness. The corresponding values after cycloplegia were 22.75 ± 0.95 mm, 519 ± 34 μm, 3.68 ± 0.16 mm, and 3.42 ± 0.20 mm, respectively. The mean lens thickness had significantly decreased ( P < 0.001) after cycloplegia, and the mean anterior chamber depth had significantly increased ( P < 0.001). The means of the axial length ( P = 0.66) and central corneal thickness ( P = 0.17) had not changed significantly. The change in lens thickness was significantly correlated with the change in anterior chamber depth ( r = −0.73, P = 0.02). The new biometer–SSOCT combination proved useful for accurately detecting changes in the anterior segment of the eye after cycloplegia in pediatric patients. The biometer’s measurements indicated increased anterior chamber depth and decreased lens thickness after cycloplegia. The anterior chamber depth increased relative to the decrease in lens thickness.

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          Clinical comparison of a new swept-source optical coherence tomography-based optical biometer and a time-domain optical coherence tomography-based optical biometer.

          To evaluate the repeatability and reproducibility of a newer swept-source optical biometer and to compare it with a standard partial coherence interferometry (PCI) biometer.
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            Repeatability and agreement in optical biometry of a new swept-source optical coherence tomography-based biometer versus partial coherence interferometry and optical low-coherence reflectometry.

            To estimate the repeatability of biometric parameters obtained with a new swept-source biometer and to compare the agreement with that of partial coherence interferometry (PCI) and optical low-coherence reflectometry (OLCR).
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              Biometry measurements using a new large-coherence-length swept-source optical coherence tomographer.

              To evaluate the repeatability and reproducibility of the measurements obtained with the Argos, a new biometer with swept-source optical coherence tomography (SS-OCT), and to compare them with the results obtained with the IOLMaster 500 (partial-coherence interferometry [PCI]) and the Lenstar LS 900 (optical low-coherence reflectometry [OLCR]) biometers.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draft
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: VisualizationRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: ResourcesRole: SupervisionRole: VisualizationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                14 August 2017
                2017
                : 12
                : 8
                : e0183378
                Affiliations
                [001]Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan
                Massachusetts Eye & Ear Infirmary, Harvard Medical School, UNITED STATES
                Author notes

                Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: Higashiyama: Senju Pharmaceutical Company: Lecture Fee, Pfizer Japan: Lecture Fee, Research grants, Alcon Japan: Research grants, Novartis Pharmaceutical Company: Research grants Iwasa: Senju Pharmaceutical Company: Lecture Fee Ohji:Alcon Japan: Consultant, Lecture Fee, Novartis Pharmaceutical Company:Consultant, Lecture Fee, Santen Pharmaceutical Company:Consultant, Lecture Fee, Bayer: Consultant, Lecture Fee, Shionogi & CO.:Consultant, Lecture Fee, Pfizer Japan:Consultant, Sanwa Kagaku Institute:Consultant, Carl Zeiss Japan:Lecture Fee, Otsuka Pharmaceutical Company:Lecture Fee, MSD:Lecture Fee, and Kowa Pharmaceutical Company:Lecture Fee This does not alter our adherence to PLOS ONE policies on sharing data and materials.

                Article
                PONE-D-17-26407
                10.1371/journal.pone.0183378
                5555612
                28806400
                967ae635-3489-4742-bbe3-e71251607fb9
                © 2017 Higashiyama et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 13 July 2017
                : 26 July 2017
                Page count
                Figures: 4, Tables: 3, Pages: 10
                Funding
                The authors received no specific funding for this work.
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Ocular System
                Ocular Anatomy
                Lens (Anatomy)
                Medicine and Health Sciences
                Anatomy
                Ocular System
                Ocular Anatomy
                Lens (Anatomy)
                Biology and Life Sciences
                Anatomy
                Head
                Eyes
                Medicine and Health Sciences
                Anatomy
                Head
                Eyes
                Biology and Life Sciences
                Anatomy
                Ocular System
                Eyes
                Medicine and Health Sciences
                Anatomy
                Ocular System
                Eyes
                Medicine and Health Sciences
                Pediatrics
                Biology and Life Sciences
                Anatomy
                Ocular System
                Ocular Anatomy
                Cornea
                Medicine and Health Sciences
                Anatomy
                Ocular System
                Ocular Anatomy
                Cornea
                Medicine and Health Sciences
                Diagnostic Medicine
                Diagnostic Radiology
                Tomography
                Research and Analysis Methods
                Imaging Techniques
                Diagnostic Radiology
                Tomography
                Medicine and Health Sciences
                Radiology and Imaging
                Diagnostic Radiology
                Tomography
                Medicine and Health Sciences
                Diagnostic Medicine
                Diagnostic Radiology
                Ultrasound Imaging
                Research and Analysis Methods
                Imaging Techniques
                Diagnostic Radiology
                Ultrasound Imaging
                Medicine and Health Sciences
                Radiology and Imaging
                Diagnostic Radiology
                Ultrasound Imaging
                Physical Sciences
                Chemistry
                Chemical Compounds
                Alkaloids
                Atropine
                Physical Sciences
                Mathematics
                Statistics (Mathematics)
                Biostatistics
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                All relevant data are within the paper and its Supporting Information files.

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