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      Fréquence et facteurs de risque maternels de la mort fœtale in utero à Kamina, République Démocratique du Congo Translated title: Frequency and Maternals risk factors of fœtal intra uterin death at Kamina, Democratic Republic of Congo

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          Abstract

          Introduction

          La mort fœtale in utero constitue un problème fréquent dans la pratique obstétricale. Les objectifs de cette étude étaient de déterminer la fréquence et d'identifier les facteurs de risque de la mort fœtale in utero à l'Hôpital Général de Référence de Kamina.

          Méthodes

          L’étude était effectuée en deux temps. En premier lieu, une étude descriptive transversale sur 379 accouchements qui avait permis de déterminer la fréquence de la mort fœtale in utero. La détermination des facteurs de risque était faite à l'aide d'une étude cas-témoins dans laquelle les caractéristiques de 53 morts in utero ont été comparées à 106 témoins constitués des naissances vivantes et à terme.

          Résultats

          La fréquence de la mort fœtale in utero à l'Hôpital Général de Référence de Kamina était de 13,9%. Après ajustement, l’âge maternel de plus de 35 ans (OR = 6,23; IC= (1,30-29,80)), l'antécédent de mort fœtale in utero (OR = 3,13; IC= (1,06-9,27)) et la maladie au cours de la grossesse (OR = 31,6, IC= (7,66-130,71)) ont été retenus comme facteurs significativement associés à l'augmentation de la survenue de la mort fœtale. L'instruction élevée de la mère (OR = 0,11; IC= IC= [0,03-0,42]) et la résidence à Kamina (OR = 0,23; IC= (0,08-0,62)) diminuaient ce risque.

          Conclusion

          La fréquence de la mort fœtale in utero était de 13,9%. L’âge maternel avancé l'antécédent de mort in utero et la maladie au cours de la grossesse étaient associés à la mort fœtale in utero mais par contre, l'instruction élevée de la femme et la résidence à Kamina diminuaient le risque. La surveillance des gestantes à risque, le dépistage et la prise en charge des maladies pendant la grossesse s'avèrent nécessaires dans la perspective de réduire la fréquence de la mort fœtale in utero dans notre milieu.

          Translated abstract

          Introduction

          Fetal intrauterine death constitutes a frequent problem in obstetric practice. The objectives of this study were to determine the frequency and to identify risk factors of fetal death at Reference General Hospital of Kamina.

          Methods

          The study was done in two times. First, a cross-sectional descriptive study of 379 deliveries which allowed to determine the frequency of fetal death. Then, the determination of risk factors was made using a case-control study in which the characteristics of 53 fetal deaths were compared to 106 controls constituted of live births.

          Results

          The fetal intrauterine death's frequency at Reference General Hospital of Kamina was at 13,98%. After adjustment, maternal age over 35 years (OR = 6,23; IC= (1,30-29,80)), antecedent of fetal intrauterine death (OR = 3,13; IC= (1,06-9,27)) and diseases during pregnancy (OR = 31,6, IC= [7,66-130,71]) have been identified as factors significantly associated with increased occurrence fetal death. The high maternal education (OR = 0,11; IC= (0,03-0,42)) and Kamina's residency (OR = 0,23; IC= (0,08-0,62)) decreased this risk.

          Conclusion

          The frequency of fetal death was 13,9%. The advanced maternal age, the history of fetal death and disease during pregnancy was associated with fetal intra uterin death but the high maternal instruction and the Kamina residence reduced the risk. The monitoring of at-risk pregnant, screening and the treatment of diseases during pregnancy are necessary in view of reducing prevalence of fetal death in our midst.

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          Most cited references27

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          Pregnancy outcome after previous stillbirth resulting from causes other than maternal conditions and fetal abnormalities.

          An adequate fetomaternal circulatory system may be compromised by a variety of disturbances leading to stillbirth. The purpose of this study was to assess subsequent pregnancy outcome in women with a history of stillbirth as a result of causes other than maternal conditions and fetal abnormalities. Ninety-two deliveries after stillbirth were identified among 11,910 deliveries of parous women recorded in the birth registry at Kuopio, Finland. Using logistic regression, pregnancy outcome measures were compared with those of a parous healthy obstetric population (n = 11,818). Women with a history of stillbirth as a result of causes other than maternal conditions and fetal abnormalities were older than their unaffected controls (32.4 yr vs 30.3 yr). Stillbirth in an earlier pregnancy was associated with a significantly higher (p < 0.001) frequency of placental abruption in subsequent pregnancy (5.4% vs 0.7%). A history of stillbirth was predictive of preterm delivery (OR = 2.25) and low-birthweight infants (OR = 2.70). No recurrence was reported. Pregnancy with a history of stillbirth as a result of causes other than maternal conditions and fetal abnormalities is a moderate risk state, with prematurity and low-birthweight rates somewhat higher than those in the general population. The overall probability of a favorable outcome is good. These findings may be useful in counseling pregnant women with a history of stillbirth.
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            Poor obstetric outcome in subsequent pregnancies in women with prior fetal death.

            Patients with recurrent first-trimester spontaneous abortion have been the subject of intensive investigation. However, relatively little is known about second- and third-trimester pregnancy loss. Thus, it is difficult for clinicians to optimally counsel, evaluate, and manage women with previous unexplained fetal death. Our objective was to ascertain the outcome of subsequent pregnancies in patients with prior fetal death. Subjects were identified from patients referred for evaluation of fetal death (occurring at >/= 10 weeks of gestation) and having at least one subsequent pregnancy. Patients with antiphospholipid antibodies were excluded. Logistic regression analysis was performed to determine the association of clinical variables with pregnancy outcome. Two hundred thirty subjects met inclusion criteria. Up through the time of their first fetal death, these women had a total of 721 pregnancies, resulting in 268 (37%) live births, 230 (32%) fetal deaths, and 200 (28%) spontaneous abortions. In total, these women had 839 subsequent pregnancies, resulting in 202 (24%) live births, 209 (25%) fetal deaths, and 372 (44%) spontaneous abortions. Univariate logistic regression analysis identified older age at pregnancy (P =.009, odds ratio 0.63, 95% confidence interval 0.42-1.03) and treatment with low-dose aspirin (P =.001, odds ratio 0.41, 95% confidence interval 0.25-0.68) to be associated with a decreased risk for subsequent pregnancy loss. Women with prior fetal death are at high risk for subsequent pregnancy loss and recurrent fetal death, with fewer than 25% of pregnancies resulting in surviving infants. These data underscore the need for additional research into the pathophysiology and prevention of recurrent fetal death.
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              Building a future for women and children.

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                Author and article information

                Journal
                Pan Afr Med J
                Pan Afr Med J
                PAMJ
                The Pan African Medical Journal
                The African Field Epidemiology Network
                1937-8688
                17 March 2016
                2016
                : 23
                : 114
                Affiliations
                [1 ]Faculté de Médecine, Département de Gynécologie et Obstétrique, Université de Kamina, République Démocratique du Congo
                [2 ]Faculté de Médecine, Département de Gynécologie et Obstétrique, Ecole de Santé Publique, Université de Lubumbashi, République Démocratique du Congo
                [3 ]Faculté de Médecine, Département de Santé Publique, Université de Kamina, République Démocratique du Congo
                Author notes
                [& ]Corresponding author: Bwana Kangulu Ignace, Faculté de Médecine, Département de Gynécologie et Obstétrique, Université de Kamina, République Démocratique du Congo
                Article
                PAMJ-23-114
                10.11604/pamj.2016.23.114.7817
                4885706
                27279941
                9699244c-45a7-4f07-8df8-a8eb634e954d
                © Ignace Bwana Kangulu et al.

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 August 2015
                : 27 February 2016
                Categories
                Research

                Medicine
                epidémiologie,mort fœtale in utero,kamina,epidemiology,fetal intrauterine death
                Medicine
                epidémiologie, mort fœtale in utero, kamina, epidemiology, fetal intrauterine death

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