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      Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

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          Abstract

          Platelet-derived growth factor (PDGF)-B-deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary microaneurysms that ruptured at late gestation. Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells. Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Jul 11 1997
          : 277
          : 5323
          Affiliations
          [1 ] Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
          Article
          10.1126/science.277.5323.242
          9211853
          969a6c38-00da-45bb-9ab0-5838e00b643f
          History

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