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Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer
Mingyang Liu ,
Yuqing Zhang ,
Jingxuan Yang ,
Hanxiang Zhan ,
Zhijun Zhou ,
Yuanyuan Jiang ,
Xiuhui Shi ,
Xiao Fan ,
Junxia Zhang ,
Wenyi Luo ,
Kar-Ming A. Fung ,
Chao Xu ,
Michael S. Bronze ,
Courtney W. Houchen ,
Min Li
April 2021
April 2021
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Abstract
Pancreatic cancer is characterized by extensive metastasis. Epithelial-mesenchymal
transition (EMT) plasticity plays a critical role in tumor progression and metastasis
by maintaining the transition between EMT and mesenchymal-epithelial transition states.
Our aim is to understand the molecular events regulating metastasis and EMT plasticity
in pancreatic cancer.