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      Linfoma de Hodgkin em baixa faixa etária: relato de dois casos Translated title: Hodgkin's lymphoma in young children: two cases report

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          Abstract

          Relato de dois casos de pacientes do sexo masculino com linfoma de Hodgkin (LH) e idades inferiores a 5 anos apresentando linfonodomegalias com evolução de alguns meses e seguimento em nosso serviço. Os estudos imuno-histopatológicos do tumor confirmaram linfoma de Hodgkin, esclerose nodular e positividade para o vírus Epstein-Barr (EBV) em material tumoral, em ambos os casos. Após período de 13 meses em remissão completa houve recidiva em um dos pacientes, mostrando doença agressiva. A análise laboratorial do tumor mostrou as mesmas características da doença inicial, e mantendo a positividade ao EBV. Uma exposição mais precoce e intensa ao EBV poderia aumentar o risco para formas muito precoces da doença e a inesperada evolução poderia estar ligada à associação do subtipo histológico e positividade ao EBV.

          Translated abstract

          The cases of two male under five-year-olds diagnosed with Hodgkin's lymphoma presenting as lymphadenopathy in evolution for some months and treated in our hospital are reported. Immunohistopathological findings of the tumors proved the existence of Hodgkin's lymphoma nodular sclerosis and positive Epstein-Barr virus in tumoral material in both cases. After 13 months of complete remission one of the patients relapsed and presented aggressive disease. Laboratorial analyses of the tumor showed the same characteristics as the initial disease including positive Epstein-Barr virus. Early and intense exposure to Epstein-Barr virus may increase the risk related to the very early development of the disease and the unexpected evolution may be connected to the association of the histological subtype and the positive Epstein-Barr virus.

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          Most cited references 18

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          The many faces of Hodgkin’s disease around the world: What have we learned from its pathology?

           N.L. Harris (1998)
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            Principles and Practice of Pediatric Oncology

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              Diehl. Molecular pathogenesis of Hodgkin's lymphoma

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rbhh
                Revista Brasileira de Hematologia e Hemoterapia
                Rev. Bras. Hematol. Hemoter.
                Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (São Paulo )
                1806-0870
                December 2006
                : 28
                : 4
                : 303-306
                Affiliations
                [1 ] Universidade de São Paulo Brazil
                [2 ] Santa Casa de Misericórdia de São Paulo Brazil
                [3 ] Universidade de São Paulo Brazil
                Article
                S1516-84842006000400018
                10.1590/S1516-84842006000400018

                http://creativecommons.org/licenses/by/4.0/

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                Product Information: website
                Categories
                HEMATOLOGY
                MEDICINE, RESEARCH & EXPERIMENTAL

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