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      Pomegranate peel extract decreases small intestine lipid peroxidation by enhancing activities of major antioxidant enzymes.

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          Abstract

          Pomegranate peel extract (PPE) contains several compounds with antioxidative properties. PPE added to foods may interact with endogenous antioxidants and promote health. However, little is known about the biochemical mechanisms by which PPE exerts their actions on tissues of biological systems in vivo. The purpose of this study was to determine the effects of PPE on activities of antioxidant enzymes. Mice were used to investigate the effects of PPE on plasma levels of malondialdehyde (MDA), tissue MDA content and activities of superoxide dismutase 1 (SOD1), SOD2 and glutathione peroxidase (GPX) in the small intestine, liver and skeletal muscle - different tissues involved in the digestion, absorption and metabolism of dietary nutrients. Control mice were fed a standard diet, whereas treated mice were fed for 40 days with the standard diet containing 5% or 10% PPE.

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          Author and article information

          Journal
          J. Sci. Food Agric.
          Journal of the science of food and agriculture
          1097-0010
          0022-5142
          Aug 2016
          : 96
          : 10
          Affiliations
          [1 ] INRA, UMR1198 Biologie du Développement et Reproduction, Département de Physiologie Animale et Systèmes D'Elevage, 78350, Jouy-en-Josas, France.
          [2 ] INRA, UMR 914, Physiologie de la Nutrition et du Comportement Alimentaire, AgroParisTech, 75005, Paris, France.
          [3 ] Unité de Biochimie Hormonale et Nutritionnelle, Centre Hospitalier Universitaire de Grenoble, Département de Biologie - Toxicologie - Pharmacologie, 38043, Grenoble cedex 9, France.
          Article
          10.1002/jsfa.7529
          26564426
          96c433d8-d93f-40c2-bead-50181b6b93f7
          © 2015 Society of Chemical Industry.
          History

          antioxidant enzymes,lipid peroxidation,mice,pomegranate peel extract,small intestine

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