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      Correction: Leukotriene Production is Increased in Abdominal Obesity

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          Abstract

          The image for Figure 1 is incorrect. Please see the corrected Figure 1 here. 10.1371/journal.pone.0117861.g001 Figure 1 Urinary leukotriene E4 (LTE4; upper panels) and serum C-reactive protein (CRP; lower panels). Waist/Hip Ratio was categorized as either low (n = 19) or high (men>0.9; women>0.85; n = 26). Triglyceride levels were categorized as either low (n = 26) or high (>1.7 mmol/L; n = 20). HDL levels were categorized as either high (n = 22) or low (<1.0 mmol/L for men, and <1.3 mmol/L for women; n = 24). Hypertension was defined as systolic blood pressure >130 mmHg, mean arterial pressure >85 mmHg or anti-hypertensive treatment (n = 19). Fasting blood glucose was categorized as either low (n = 38) or high (>5 mmol/L; n = 8). P-value (obtained by means of Mann-Whitney Rank Sum Test) in bold font indicates P<0.05.

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          Leukotriene Production Is Increased in Abdominal Obesity

          Obesity is a major risk factor for insulin resistance and type-2 diabetes. A chronic low grade inflammatory state has been described during obesity and associated with insulin resistance pathogenesis. Results from animal studies are in favor of a role of the leukotriene (LT) pathway in obesity induced-insulin resistance. However, there is a paucity of data regarding this association in human obesity. Therefore, the aim of this study was to investigate whether LT production was associated with insulin resistance and other metabolic parameters in a cohort of obese subjects. Forty-six (70% females) obese subjects (BMI≧30 kg/m2) without known diabetes and without inflammatory disease (CRP<10 mg/l) were included. Median age was 44 years (16–80) with a median BMI of 36.8 kg/m2 (30–51). Insulin resistance was evaluated by HOMA-IR index and glucose tolerance test. Urinary LTE4 (U-LTE4) concentration was measured by enzyme immune assay. Screening for obstructive sleep apnea was performed. There was a positive association of U-LTE4 with waist to hip ratio, systolic blood pressure and HOMA-IR in univariate analysis. Further, waist to hip ratio remained the only parameter significantly correlated with U-LTE4, in adjusted multivariate analysis. Taken together, these results confirm the previously established notion of chronic low grade inflammation in obesity and further suggests a role for the LT pathway in obesity-associated development of insulin resistance in humans.
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            Journal
            PLoS One
            PLoS ONE
            plos
            plosone
            PLoS ONE
            Public Library of Science (San Francisco, CA USA )
            1932-6203
            2015
            23 January 2015
            : 10
            : 1
            : e0117861
            Article
            PONE-D-15-00405
            10.1371/journal.pone.0117861
            4304838
            25615625
            96cc6120-4ff2-407e-8b1a-ceb2061de456
            Copyright @ 2015

            This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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