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      Metabolic profile of rosmarinic acid from Java tea ( Orthosiphon stamineus ) by ultra‐high‐performance liquid chromatography coupled to quadrupole‐time‐of‐flight tandem mass spectrometry with a three‐step data mining strategy

      1 , 1 , 1 , 1 , 2 , 1
      Biomedical Chromatography
      Wiley

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          Tissue Distribution, Excretion and Metabolic Profile of Dihydromyricetin, a Flavonoid from Vine Tea (Ampelopsis grossedentata) after Oral Administration in Rats.

          Dihydromyricetin (DMY), a flavanonol compound found as the most abundant and bioactive constituent in vine tea (Ampelopsis grossedentata), possesses numerous biological activities. In the present study, a HPLC-MS/MS method for the determination of DMY in tissues, urine and feces was developed and applied to the tissue distribution and excretion study after oral administration in rats, and the metabolic profile of DMY was further investigated using UPLC-QTOF-MS. The results indicated that DMY could be distributed rapidly in various tissues and highly in gastrointestinal tract. The elimination of DMY occurred rapidly as well, and most unconverted forms were excreted in feces. A total of eight metabolites were identified in urine and feces, while metabolites were hardly found in plasma. The predicted metabolic pathways including reduction, dehydroxylation, methylation, glucuronidation and sulfation were proposed. The present findings may provide the theoretical basis for evaluating the biological activities of DMY, and will be helpful for its future development and application.
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            Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo.

            High mobility group box 1 (HMGB1) protein is a crucial cytokine that mediates response to infection, injury, and inflammation. Rosmarinic acid (RA) is an important component of the leaves of Perilla frutescens and has neuroprotective, anti-microbial, anti-oxidant, and anti-cancer effects but little is known of its effects on HMGB1-mediated inflammatory response. Here, we investigated this issue by monitoring the effects of RA on the lipopolysaccharide (LPS) or cecal ligation and puncture (CLP)-mediated release of HMGB1 and HMGB1-mediated modulation of inflammatory responses. RA potently inhibited the release of HMGB1 and down-regulated HMGB1-dependent inflammatory responses in human endothelial cells. RA also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in mice. Furthermore, RA reduced CLP-induced HMGB1 release and sepsis-related mortality. Given these results, RA should be viewed as a candidate therapeutic agent for the treatment of various inflammatory diseases via inhibition of the HMGB1 signaling pathway.
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              Chemicalome and metabolome profiling of polymethoxylated flavonoids in Citri Reticulatae Pericarpium based on an integrated strategy combining background subtraction and modified mass defect filter in a Microsoft Excel Platform

              Detection of metabolites in complex biological matrixes is a great challenge because of the background noise and endogenous components. Herein, we proposed an integrated strategy that combined background subtraction program and modified mass defect filter (MMDF) data mining in a Microsoft Excel platform for chemicalome and metabolome profiling of the polymethoxylated flavonoids (PMFs) in Citri Reticulatae Pericarpium (CRP). The exogenously-sourced ions were firstly filtered out by the developed Visual Basic for Applications (VBA) program incorporated in the Microsoft Office. The novel MMDF strategy was proposed for detecting both target and untarget constituents and metabolites based on narrow, well-defined mass defect ranges. The approach was validated to be powerful, and potentially useful for the metabolite identification of both single compound and homologous compound mixture. We successfully identified 30 and 31 metabolites from rat biosamples after oral administration of nobiletin and tangeretin, respectively. A total of 56 PMFs compounds were chemically characterized and 125 metabolites were captured. This work demonstrated the feasibility of the integrated approach for reliable characterization of the constituents and metabolites in herbal medicines.
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                Author and article information

                Journal
                Biomedical Chromatography
                Biomedical Chromatography
                Wiley
                0269-3879
                1099-0801
                May 22 2019
                September 2019
                June 06 2019
                September 2019
                : 33
                : 9
                Affiliations
                [1 ]The National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal MedicineJiangxi University of Traditional Chinese Medicine Jiangxi Nanchang China
                [2 ]Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of EducationJiangxi University of Traditional Chinese Medicine Nanchang China
                Article
                10.1002/bmc.4599
                96cf8a3e-14a3-4fd7-a690-0fc1a37f6bce
                © 2019

                http://onlinelibrary.wiley.com/termsAndConditions#vor

                http://doi.wiley.com/10.1002/tdm_license_1.1

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