Contributors
Hu Zhang: Role: Data curationRole: Formal analysisRole: InvestigationRole: Methodology
Ryan Gordon: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: Validation
Wenqi Li: Role: Data curationRole: Formal analysisRole: Investigation
Ximing Yang: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administration
Abhinandan Pattanayak:
ORCID: http://orcid.org/0000-0001-5822-6430
Role: Investigation
Graham Fowler: Role: Investigation
Limin Zhang: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Resources
William J. Catalona: Role: Data curationRole: Resources
Yongzeng Ding: Role: Data curationRole: Investigation
Li Xu: Role: ConceptualizationRole: InvestigationRole: Methodology
Xiaoke Huang: Role: Investigation
Borko Jovanovic: Role: Data curationRole: Formal analysisRole: Methodology
David L. Kelly: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Methodology
Haowen Jiang: Role: ConceptualizationRole: ResourcesRole: Supervision
Raymond Bergan:
ORCID: http://orcid.org/0000-0001-8690-4876
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: Writing – original draftRole: Writing – review & editing
Aamir Ahmad: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
27
March
2019
Publication date Collection: 2019
Volume: 14
Issue: 3
Electronic Location Identifier: e0214078
Affiliations
[1
]
Division of Hematology/Oncology, Knight Cancer Institute, Oregon Health & Science
University, Portland, Oregon, United States of America
[2
]
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China
[3
]
Department of Pathology, Northwestern University, Chicago, Illinois, United States
of America
[4
]
Department of Urology, Northwestern University, Chicago, Illinois, United States of
America
[5
]
Department of Medicine, Northwestern University, Chicago, Illinois, United States
of America
[6
]
Department of Gastroenterology, Xiang’an Hospital of Xiamen University, FujianXiamen,
China
[7
]
Department of Preventive Medicine, Northwestern University, Chicago, Illinois, United
States of America
[8
]
Fred & Pamela Buffet Cancer Center, University Nebraska Medical Center, Omaha, Nebraska,
United States of America
University of South Alabama Mitchell Cancer Institute, UNITED STATES
Author notes
Competing Interests: I have read the journal's policy and the authors of this manuscript have the following
competing interests: This does not alter our adherence to PLOS ONE policies on sharing
data and materials. Patents awarded: 1. Catalytic Enantioselective Synthesis of Flavanones
and Chromanones (US Patent # 7,851,640). Role: inventor. 2. Inhibition and Treatment
of Prostate Cancer Metastasis (US Patent #s: 8,481,760, 8,742,141). Role: inventor.
3. Inhibition of Cancer Cell Motility (U.S. Patent #: 9,839,625). Role: inventor.
Description: Work in point #1 describes the synthesis of new compounds that have the
potential to inhibit cancer cell motility. Work in points 2 and 3 describes a different
class of new compounds that do inhibit cancer cell motility and metastasis, and also
identify a novel biological target for inhibiting those processes. That novel biological
target involves selective modulation of HSP90 activity. Patents pending: Cell free
screen for measuring effect of small molecules on client protein interactions with
the HSP90B/CDC37 complex and resultant functional effects (US Patent Pending: U.S.
Serial No. 62/628,243 -- VA ID No. 2017-383; A&A Ref. 30452.43USP1) Description: work
in this pending application describes an in vitro method for screening of compounds
that are selective HSP90 modulator Division of Hematology & Medical Oncology
www.ohsu.edu/cancer. Cover Letter Page 2 of 2, Ownership interests: Raymond Bergan has the following
relationships with Third Coast Therapeutics (3CRx) Inc.: cofounder, co-owner, member
board of directors, Chief Scientific Officer. The focus of 3CRx is to move therapeutics
licensed under above patents into human clinical trials to assess whether they will
inhibit cancer cell motility and metastasis.
Author information
Article
Publisher ID:
PONE-D-18-28484
DOI: 10.1371/journal.pone.0214078
PMC ID: 6436751
PubMed ID: 30917169
SO-VID: 96d20e7d-4fe4-4024-be64-587c7b9f884d
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 7
October
2018
Date
accepted
: 6
March
2019
Page count
Figures: 4,
Tables: 2,
Pages: 19
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100000738, U.S. Department of Veterans Affairs;
Award ID: IBX002842A
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8690-4876
Raymond Bergan
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: CA122985
Award Recipient
:
Hu Zhang
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: CA90386
Award Recipient
:
ORCID: http://orcid.org/0000-0001-8690-4876
Raymond Bergan
Funded by: funder-id http://dx.doi.org/10.13039/501100003399, Science and Technology Commission of Shanghai Municipality;
Award ID: 16140903600
Award Recipient
:
Haowen Jiang
This study was supported with funding to R.B. by the U.S. Department of Veterans Affairs
(IBX002842A) and the National Institutes of Health (R01 CA122985, Prostate SPORE CA90386
and P30 CA069533), and to H.J. from grant (16140903600) from Science and Technology
Commission Shanghai Municipality. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Prostate Gland
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Exocrine Glands
Subject:
Prostate Gland
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Genitourinary Tract Tumors
Subject:
Prostate Cancer
Subject:
Medicine and Health Sciences
Subject:
Urology
Subject:
Prostate Diseases
Subject:
Prostate Cancer
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Metastasis
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Basic Cancer Research
Subject:
Metastasis
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Motility
Subject:
People and Places
Subject:
Population Groupings
Subject:
Ethnicities
Subject:
Chinese People
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Treatment
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