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      Prolactin inhibits the steroidogenesis in midfollicular phase human granulosa cells cultured in a chemically defined medium.

      1 ,
      Fertility and sterility

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          Abstract

          In vitro studies were conducted on prolactin (PRL) effects on human granulosa cell steroidogenesis. Cells derived from healthy midfollicular phase follicles were cultured in a chemically defined medium supplemented with androstenedione (delta 4 A) 10(-7) M. Cultures treated with follicle-stimulating hormone (FSH) showed a dose-dependent increase of estradiol (E2) and progesterone (P) secretion. The authors demonstrated that PRL (greater than or equal to 10 ng/ml) inhibits basal as well as FSH (10 ng/ml)-stimulated E2 and P secretion. This PRL effect was overcome only by FSH maximal stimulating doses (100 ng/ml). These results suggest a direct inhibitory effect of PRL on granulosa cell steroidogenesis acting as a negative modulator of FSH action. These effects might be related to the ovarian dysfunction observed in hyperprolactinemia.

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          Author and article information

          Journal
          Fertil. Steril.
          Fertility and sterility
          0015-0282
          0015-0282
          Apr 1988
          : 49
          : 4
          Affiliations
          [1 ] National Institute of Endocrinology, World Health Organization Collaborating Center, Habana, Cuba.
          Article
          S0015-0282(16)59831-8
          3127246
          96ef3500-1eaf-4ac7-9896-14e4013d2999
          History

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