Blog
About

32
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

      Nature genetics

      African Americans, genetics, Prostatic Neoplasms, Polymorphism, Single Nucleotide, Male, Humans, Haplotypes, methods, Genomics, Genetic Variation, Genetic Predisposition to Disease, Genetic Linkage, European Continental Ancestry Group, Europe, Chromosomes, Human, Pair 8, United States

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence and mortality rates. Here we report a second genetic variant in the 8q24 region that, in conjunction with another variant we recently discovered, accounts for about 11%-13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans. We made the current discovery through a genome-wide association scan of 1,453 affected Icelandic individuals and 3,064 controls using the Illumina HumanHap300 BeadChip followed by four replication studies. A key step in the discovery was the construction of a 14-SNP haplotype that efficiently tags a relatively uncommon (2%-4%) susceptibility variant in individuals of European descent that happens to be very common (approximately 42%) in African Americans. The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis.

          Related collections

          Author and article information

          Journal
          17401366
          10.1038/ng1999

          Comments

          Comment on this article