Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

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Abstract

The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells (ECs), the building blocks of islet microvasculature. Intra-islet ECs, actively regulate vascular permeability and appear to play a role in fine-tuning blood glucose sensing and regulation. These cells also tend to behave as “guardians”, controlling the expression and movement of a number of important immune mediators, thereby strongly contributing to the physiology of islets. This review will focus on the molecular signalling and crosstalk between the intra-islet ECs and β-cells and how their relationship can be a potential target for intervention strategies in islet pathology and islet transplantation.

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Author and article information

Journal

Journal ID (nlm-ta): World J Transplant

Journal ID (publisher-id): WJT

Title: World Journal of Transplantation

Publisher: Baishideng Publishing Group Inc

ISSN (Electronic): 2220-3230

Publication date (Print): 24 April 2017

Publication date (Electronic): 24 April 2017

Volume: 7

Issue: 2

Pages: 117-128

Affiliations

Siddharth Narayanan, Gopalakrishnan Loganathan, Maheswaran Dhanasekaran, William Tucker, Ankit Patel, SriPrakash Mokshagundam, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, Louisville, KY 40202, United States

Venugopal Subhashree, School of Biosciences and Technology, VIT University, Vellore 632014, India

Author notes

Author contributions: All authors contributed to this paper.

Correspondence to: Appakalai N Balamurugan, PhD, Clinical Islet Cell Laboratory, Center for Cellular Transplantation, Cardiovascular Innovation Institute, Department of Surgery, University of Louisville, 302 E Muhammad Ali Blvd., Louisville, KY 40202, United States. bala.appakalai@ 123456louisville.edu

Telephone: +1-502-7947070 Fax: +1-502-8540558

Article

Other ID: jWJT.v7.i2.pg117

DOI: 10.5500/wjt.v7.i2.117

PMC ID: 5409911

SO-VID: 96fbf391-bc71-47af-80cf-b5fc9ec46d45

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Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation

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Abstract

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Gamma Delta T cells

Most cited references 147

Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication.

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.

Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.

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