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      LncRNA CRNDE is a biomarker for clinical progression and poor prognosis in clear cell renal cell carcinoma.

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          Abstract

          Colorectal neoplasia differentially expressed (CRNDE) served as an oncogenic long noncoding RNA (lncRNA) to be involved in the initialization and development of human cancers. However, the clinical significance and biological function of CRNDE in clear cell renal cell carcinoma (ccRCC) was not fully understood. In our study, we found CRNDE levels were increased in ccRCC tissue specimens and cell lines, and corrected with advanced clinical stage, large tumor size, lymph node metastasis, distant metastasis, and poor pathological grade in patients with ccRCC. Furthermore, levels of CRNDE were negatively correlated with overall survival of patients with ccRCC, and high-expression of CRNDE was an independent poor prognostic factor for patients with ccRCC. Moreover, loss-of-function and gain-of-function approaches showed CRNDE-enhanced ccRCC cell migration and invasion through modulating EMT-associated genes. In conclusion, CRNDE acts as an oncogenic lncRNA in ccRCC.

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          Author and article information

          Journal
          J. Cell. Biochem.
          Journal of cellular biochemistry
          Wiley
          1097-4644
          0730-2312
          Dec 2018
          : 119
          : 12
          Affiliations
          [1 ] Department of Kidney Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
          [2 ] Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, China.
          [3 ] Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.
          Article
          10.1002/jcb.27389
          30129055
          9707b42a-a178-450e-9305-0cb1bdc364d8
          History

          colorectal neoplasia differentially expressed (CRNDE),metastasis,renal carcinoma,biomarker

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