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      A Light and Electron Microscopic Study of Renal Tubular Regeneration

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      Nephron

      S. Karger AG

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          Abstract

          Acute renal necrosis of the distal or straight portion of the proximal convoluted tubule was induced in the mouse kidney with an intraperitoneal injection of uranyl nitrate. Regeneration of the tubular epithelium occurred via mitotic proliferation of the cells in a zone of dedifferentiation which developed at the cortico-medullary interface with migration of the cells proximally up the nephron. Re-epifhelialization was essentially complete within five days of the injection. The new cells at first developed organelles associated with synthesis of protein, i.e. RNP particles, rough surfaced ER, prominent Golgi apparatus and increased numbers of nuclear pores. Once the tubular cell mass has been reconstituted, this specialized machinery was replaced over the course of the first 7–10 days by microvilli, large numbers of mitochondria and basal infoldings thus adapting the cell for the process of re-absorption. No acute glomerular lesions and only rare chronic tubular alterations were seen.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1968
          1968
          26 November 2008
          : 5
          : 4
          : 249-264
          Affiliations
          Edwin S. Webster Memorial Laboratories, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
          Article
          179635 Nephron 1968;5:249–264
          10.1159/000179635
          5670178
          © 1968 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 16
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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