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      NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.

      1 , 2 , 3
      Cell metabolism

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          Abstract

          NAD(+) has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded protein response. This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. In this review, we summarize how NAD(+) metabolism links energy status with adaptive cellular and organismal responses and how this knowledge can be therapeutically exploited.

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          Author and article information

          Journal
          Cell Metab.
          Cell metabolism
          1932-7420
          1550-4131
          Jul 7 2015
          : 22
          : 1
          Affiliations
          [1 ] Nestlé Institute of Health Sciences, 1015 Lausanne, Switzerland.
          [2 ] Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.
          [3 ] Laboratory of Integrative and Systems Physiology, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. Electronic address: admin.auwerx@epfl.ch.
          Article
          S1550-4131(15)00266-1 NIHMS696097
          10.1016/j.cmet.2015.05.023
          26118927
          97209e59-4722-4ac2-8533-8435ddaf86fc
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

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