Brain‐Targeted Exosomes‐Based Drug Delivery System to Overcome the Treatment Bottleneck of Brainstem Glioma

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Abstract

Brain health is the humans’ primary goal in achieving health and longevity. Brainstem glioma (BSG) has a high disability and mortality rate, posing a serious threat to children's brain health. Delivery of drugs to the brainstem is limited by poor tumor targeting and low blood‐brain barrier (BBB) permeability. Thus, it is a great challenge to construct intracranial drug delivery systems with strong biocompatibility, low immunogenicity, and high BBB permeability for the delivery of drugs targeting BSG. Exosomes, as the next generation of novel delivery systems, have been widely used to across the BBB due to their advantages of good biocompatibility, stability, and permeability of the BBB and have made corresponding breakthroughs in targeted drug delivery for CNS diseases. This review summarizes natural, polypeptide functionalized, and physical methods‐assisted brain‐targeted exosomes‐based drug delivery systems, the drug treatment bottleneck of BSG, and highlights the potential of using a brain‐targeted exosomes‐based drug delivery system to overcome the drug treatment bottleneck of BSG. It provides new insights into using exosomes‐based drug delivery for BSG treatment.

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Most cited references 173

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Author and article information

Contributors

Junge Chen: (View ORCID Profile)

Xing‐Jie Liang: (View ORCID Profile)

Journal

Title: Advanced Functional Materials

Abbreviated Title: Adv Funct Materials

Publisher: Wiley

ISSN (Print): 1616-301X

ISSN (Electronic): 1616-3028

Publication date Created: August 2023

Publication date (Electronic): May 2023

Publication date (Print): August 2023

Volume: 33

Issue: 33

Affiliations

[1 ] Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineering School of Engineering Medicine Beihang University Beijing 100083 P. R. China

[2 ] CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Beijing 100190 P. R. China

[3 ] Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 P. R. China

[4 ] China National Clinical Research Center for Neurological Diseases (NCRC‐ND) Beijing 100070 P. R. China

Article

DOI: 10.1002/adfm.202302378

SO-VID: 973ca76c-6282-4627-bde3-3911b1670120

License:

http://onlinelibrary.wiley.com/termsAndConditions#vor

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