Contributors
Josephe A. Honorat: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Project administrationRole:
Writing – original draft
Yuji Nakatsuji: Role: ConceptualizationRole: Formal analysisRole: Project administration
Mikito Shimizu: Role: Formal analysisRole: Investigation
Makoto Kinoshita: Role: Project administration
Hisae Sumi-Akamaru: Role: Formal analysisRole: Investigation
Tsutomu Sasaki: Role: Project administration
Kazushiro Takata: Role: Project administration
Toru Koda: Role: Project administration
Akiko Namba: Role: Formal analysis
Kazuya Yamashita: Role: Formal analysis
Eri Sanda: Role: Formal analysisRole: Investigation
Manabu Sakaguchi: Role: Formal analysisRole: Investigation
Atsushi Kumanogoh: Role: Formal analysis
Takashi Shirakura: Role: Project administration
Mizuho Tamura: Role: Project administration
Saburo Sakoda: Role: Project administration
Hideki Mochizuki: Role: Project administration
Tatsusada Okuno:
ORCID: http://orcid.org/0000-0001-6173-3759
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: Project administration
Akio Suzumura: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
6
November
2017
Publication date Collection: 2017
Volume: 12
Issue: 11
Electronic Location Identifier: e0187215
Affiliations
[1
]
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka,
Japan
[2
]
Department of Neurology, Osaka General Medical Center, Osaka, Osaka, Japan
[3
]
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University
Graduate School of Medicine, Suita, Osaka, Japan
[4
]
Pharmaceutical Development Research Laboratories, Teijin Pharma Ltd., Hino, Tokyo,
Japan
[5
]
Department of Neurology, National Hospital Organization Toneyama National Hospital,
Toyonaka, Osaka, Japan
Author notes
Competing Interests: Takashi Shirakura and Mizuho Tamura were employees of Teijin Pharma Ltd. The drug
febuxostat used in the study was kindly provided by Teijin Pharma Ltd. This does not
alter our adherence to PLoS One policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-17-26460
DOI: 10.1371/journal.pone.0187215
PMC ID: 5673182
PubMed ID: 29107957
SO-VID: 974048b9-4678-4b85-a7c4-92a92f269c29
Copyright © © 2017 Honorat et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 14
July
2017
Date
accepted
: 16
October
2017
Page count
Figures: 4,
Tables: 0,
Pages: 12
Funding
This study is supported in part by the Practical Research Project for Rare/Intractable
Diseases of the Japan Agency for Medical Research and Development (AMED), JSPS KAKENHI
(grant numbers JP26461293 and JP15K09339), and a Health and Labor Sciences Research
Grant for Rare and Intractable Diseases from the Ministry of Health, Labor and Welfare
of Japan. Teijin Pharma Ltd. provided support in the form of salaries for authors
T.S. and M.T., but did not have any additional role in the study design, data collection
and analysis, decision to publish, or preparation of the manuscript. The specific
roles of these authors are articulated in the 'author contributions' section.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Central Nervous System
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Gene regulation
Subject:
Small interfering RNAs
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
Non-coding RNA
Subject:
Small interfering RNAs
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Nervous System
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Neuroanatomy
Subject:
Spinal Cord
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Research and Analysis Methods
Subject:
Bioassays and Physiological Analysis
Subject:
Microarrays
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