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      An abscopal response to radiation and ipilimumab in a patient with metastatic non-small cell lung cancer.

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          Abstract

          A posteriori evidence suggests that radiotherapy to a targeted tumor can elicit an immune-mediated abscopal (ab-scopus, away from the target) effect in non-targeted tumors, when combined with an anti-cytotoxic T-lymphocyte antigen-4 monoclonal (CTLA-4) antibody. Concurrent radiotherapy and ipilimumab (a human monoclonal anti-CTLA-4 antibody) induced immune-mediated abscopal effects in poorly immunogenic pre-clinical tumor models and metastatic melanoma patients. However, no such reports exist for patients with metastatic lung adenocarcinoma. We report the first abscopal response in a treatment-refractory lung cancer patient treated with radiotherapy and ipilimumab. A post-treatment increase in tumor-infiltrating cytotoxic lymphocytes, tumor regression, and normalization of tumor markers was observed. One year after treatment with concurrent radiotherapy and ipilimumab the patient is without evidence of disease.

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          Author and article information

          Journal
          Cancer Immunol Res
          Cancer immunology research
          American Association for Cancer Research (AACR)
          2326-6074
          2326-6066
          Dec 2013
          : 1
          : 6
          Affiliations
          [1 ] Department of Radiation Oncology, New York University School of Medicine, New York, NY.
          [2 ] Department of Radiation Oncology, New York University School of Medicine, New York, NY ; Department of Pathology, New York University School of Medicine, New York, NY.
          [3 ] Department of Medicine, New York University School of Medicine, New York, NY.
          Article
          NIHMS542983
          10.1158/2326-6066.CIR-13-0115
          3930458
          24563870
          974ebebb-cb55-4e0b-8721-3f46430854f5
          History

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