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      Effects of Dorsal Fornix Section and Hippocampectomy on Adrenocortical Responses to Sensory Stimulation in the Rat

      ,

      Neuroendocrinology

      S. Karger AG

      Adrenocortical responses, Neural pathways, Fornix, Hippocampus, Sensory stimuli

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          Abstract

          With the purpose of identifying the neural structures which are involved in the mediation of the adrenocortical responses to photic, acoustic and sciatic nerve stimulation, experiments were conducted on male rats with bilateral section of the dorsal fornix and dorsal or ventral hippocampectomies. The basal corticosterone levels in these animals were not significantly different from those in controls. Stimulation of the 3 sensory modalities produced normal adrenocortical responses in rats with fornix section. The hippocampectomies had no effect or only a marginal effect on the response to ether stress and to photic and acoustic stimulation; however, the adrenal response to sciatic stimulation was very significantly reduced. The data demonstrate the participation of the hippocampus in the transmission of somatosensory responses which promote adrenocortical activity. The efferent connections of the hippocampus to the hypothalamus which are involved in this mechanism are discussed.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 22
          : 1
          : 1-7
          Affiliations
          Laboratory of Neurophysiology, Department of Neurology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem
          Article
          122607 Neuroendocrinology 1976;22:1–7
          10.1159/000122607
          1025483
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 7
          Categories
          Paper

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