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      Increased Thyroidal T 4/T 3 Ratio in Nodular and Paranodular Tissues of Nontoxic Goiter following Suppressive Treatment with Thyroid Hormones

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          The effect of suppressive treatment with thyroid hormones on thyroidal iodothyronines and T<sub>4</sub>/T<sub>3</sub> ratio in nodular and paranodular tissues was investigated in 12 patients with nontoxic goiter. Results were compared to those from 11 nontreated patients. Continuous thyroid hormone administration produced a significant increase in thyroidal T<sub>4 </sub>and T<sub>4</sub>/T<sub>3</sub> ratio in nodular tissues while T<sub>3</sub> remained unchanged. In paranodular tissues a significant rise of T<sub>4</sub>/T<sub>3</sub> ratio, an insignificant increase in T<sub>4</sub> and a decrease in T<sub>3</sub> were observed following the administration of thyroid hormones. The results are very similar to those obtained in paranodular tissue of autonomously functioning thyroid nodule, and are probably the consequence of suppressed TSH secretion, as TSH predominantly stimulates the synthesis of T<sub>3</sub> and/or thyroidal T<sub>4</sub> monodeiodination.

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          Author and article information

          Hormone Research in Paediatrics
          S. Karger AG
          28 November 2008
          : 25
          : 3
          : 147-151
          aDepartment of Medicine, Division of Endocrinology and bDepartment of Otorhynolaryngology, Dr. M. Stojanović University Hospital, Zagreb, Yugoslavia
          180646 Horm Res 1987;25:147–151
          © 1987 S. Karger AG, Basel

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