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      Increased Thyroidal T 4/T 3 Ratio in Nodular and Paranodular Tissues of Nontoxic Goiter following Suppressive Treatment with Thyroid Hormones

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          Abstract

          The effect of suppressive treatment with thyroid hormones on thyroidal iodothyronines and T<sub>4</sub>/T<sub>3</sub> ratio in nodular and paranodular tissues was investigated in 12 patients with nontoxic goiter. Results were compared to those from 11 nontreated patients. Continuous thyroid hormone administration produced a significant increase in thyroidal T<sub>4 </sub>and T<sub>4</sub>/T<sub>3</sub> ratio in nodular tissues while T<sub>3</sub> remained unchanged. In paranodular tissues a significant rise of T<sub>4</sub>/T<sub>3</sub> ratio, an insignificant increase in T<sub>4</sub> and a decrease in T<sub>3</sub> were observed following the administration of thyroid hormones. The results are very similar to those obtained in paranodular tissue of autonomously functioning thyroid nodule, and are probably the consequence of suppressed TSH secretion, as TSH predominantly stimulates the synthesis of T<sub>3</sub> and/or thyroidal T<sub>4</sub> monodeiodination.

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          Author and article information

          Journal
          Journal ID (publisher-id): HRE
          Journal ID (doi): 10.1159/issn.0018-5051
          Title: Hormone Research in Paediatrics
          Publisher: S. Karger AG
          ISSN (Print): 0018-5051
          ISSN (Electronic): 2571-6603
          Publication date Subscription-year: 1987
          Publication date (Print): 1987
          Publication date (Electronic): 28 November 2008
          Volume: 25
          Issue: 3
          Pages: 147-151
          Affiliations
          aDepartment of Medicine, Division of Endocrinology and bDepartment of Otorhynolaryngology, Dr. M. Stojanović University Hospital, Zagreb, Yugoslavia
          Article
          Publisher ID: 180646 Other ID: Horm Res 1987;25:147–151
          DOI: 10.1159/000180646
          SO-VID: 97ac7ce5-010e-456d-bca4-f2e8f03e1235
          Copyright © © 1987 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date received : 10 March 1986
          Date accepted : 05 September 1986
          Page count
          Pages: 5
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Keywords: Thyroidal T4/T3 ratio,Thyroidal iodothyronines,Suppressive treatment,Nontoxic goiter
          Data availability:
          ScienceOpen disciplines: Endocrinology & Diabetes, Neurology, Nutrition & Dietetics, Sexual medicine, Internal medicine, Pharmacology & Pharmaceutical medicine
          Keywords: Thyroidal T4/T3 ratio, Thyroidal iodothyronines, Suppressive treatment, Nontoxic goiter

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