Blog
About

5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Inhibitors of P450-dependent steroid biosynthesis: From research to medical treatment

      The Journal of Steroid Biochemistry and Molecular Biology

      Elsevier BV

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references 117

          • Record: found
          • Abstract: found
          • Article: not found

          Biological actions of androgens.

          Though unnecessary for life itself, androgens are essential for the propagation of the species and for establishment and maintenance of the quality of life of males through their support of sexual behavior and function, muscle strength, and sense of well-being. In carrying out its many functions, T acts both as hormone and prohormone. It is an outstanding example of the diverse evolutionary utilization of a primitive informational molecule both among and within species. Not only does T act through the androgen receptor both unchanged and via 5 alpha-reduction, but it acts in tissues with a high aromatase level as an estrogen via the estrogen receptor. Furthermore, DHT, binding to the estrogen receptor, can act as an inhibitor of estrogen action. The products of androgen metabolism may also play active regulatory roles in hematopoiesis and in the regulation of certain hepatic enzymes. Table 3 summarizes the actions of secreted T in males indicating the probable effector hormone. While gross hypogonadism is uncommon, mild androgen insufficiency may be much more frequent, especially in older men, and in those receiving treatment for chronic medical conditions. It is quite possible that such individuals would benefit from appropriate androgen therapy were it available, but the current forms of replacement therapy are not very satisfactory. Better approaches are required. With the exception of a small number of secreted proteins, the products of transcription induced by androgens are not, as yet, known. When the androgen receptor gene is cloned it will be possible to identify androgen-regulated genes and their products. It will then be possible to design agents selectively producing specific desired androgenic effects.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            The endocrinology and developmental biology of the prostate.

              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              STUDIES ON PROSTATIC CANCER

                Bookmark

                Author and article information

                Journal
                The Journal of Steroid Biochemistry and Molecular Biology
                The Journal of Steroid Biochemistry and Molecular Biology
                Elsevier BV
                09600760
                December 1992
                December 1992
                : 43
                : 8
                : 1003-1021
                Article
                10.1016/0960-0760(92)90328-G
                © 1992

                http://www.elsevier.com/tdm/userlicense/1.0/

                Comments

                Comment on this article