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      The gut microbiota, bacterial metabolites and colorectal cancer.

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          Abstract

          Accumulating evidence suggests that the human intestinal microbiota contributes to the aetiology of colorectal cancer (CRC), not only via the pro-carcinogenic activities of specific pathogens but also via the influence of the wider microbial community, particularly its metabolome. Recent data have shown that the short-chain fatty acids acetate, propionate and butyrate function in the suppression of inflammation and cancer, whereas other microbial metabolites, such as secondary bile acids, promote carcinogenesis. In this Review, we discuss the relationship between diet, microbial metabolism and CRC and argue that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.

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          Author and article information

          Journal
          Nat Rev Microbiol
          Nature reviews. Microbiology
          Springer Science and Business Media LLC
          1740-1534
          1740-1526
          Oct 2014
          : 12
          : 10
          Affiliations
          [1 ] Microbiology Group, Rowett Institute of Nutrition and Health, University of Aberdeen, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK.
          [2 ] Gastrointestinal Research Group, Division of Applied Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK.
          Article
          nrmicro3344
          10.1038/nrmicro3344
          25198138
          97d13bec-fcab-46ba-bdd6-ac72914eb887
          History

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