We investigated the abilities of four fundamental frequency (F0)-dependent and two F0-independent measures to quantify vocal noise. Two of the F0-dependent measures were computed in the time domain, and two were computed using spectral information from the vowel. The F0-independent measures were based on the linear prediction (LP) modeling of vowel samples. Tests using a database of sustained vowel samples, collected from 53 normal and 175 pathological talkers, showed that measures based on the LP model were much superior to the other measures. A classification rate of 96.5% was achieved by a parameter that quantifies the spectral flatness of the unmodeled component of the vowel sample.