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Editor-in-Chief/Editor for Review Articles Yusuke Nakamura The University of Chicago Deputy Editor-in-Chief Kohei Miyazono The University of Tokyo Editors Hiroyuki Mano The University of Tokyo Hitoshi Nakagama National Cancer Center Tomoki Naoe Nagoya University Masahide Takahashi Nagoya University Ryuzo Ueda Aichi Medical University Editor Emeritus Takashi Sugimura Associate Editors Richard J. Ablin Hiroyuki Aburatani Hideyuki Akaza Shin-ichi Akiyama Tetsu Akiyama Yuichi Ando Hirofumi Arakawa Suk-Chul Bae Yung-Jue Bang William T. Beck Maarten C. Bosland Xuetao Cao Anthony T.C. Chan Yao-Tseng Chen Tommaso A. Dragani Keigo Endo Hiroyasu Esumi Soldano Ferrone Naoya Fujita Masashi Fukayama Yoichi Furukawa Michael M. Gottesman Parry Guilford Koichi Hagiwara Nobuyuki Hamajima Hideyoshi Harashima Curtis C. Harris Kiyohiko Hatake Masanori Hatakeyama Carl-Henrik Heldin Shigeki Higashiyama Okio Hino Atsushi Hirao Masahiro Hiraoka Seiichi Hirota Chung-cheng Hsieh Kay Huebner Hidenori Ichijo Kohzoh Imai Katsumi Imaida Takeshi Imamura Masaya Imoto Johji Inazawa Jun-ichiro Inoue Fuyuki Ishikawa Yuichi Ishikawa Chikashi Ishioka Kyogo Itoh Atsushi Iwama David H. Johnson Yae Kanai Yuzuru Kanakura Shuichi Kaneko Mari Kannagi Reiji Kannagi Jun Kanno Toyomasa Katagiri Mitsuyasu Kato Yutaka Kawakami Elliott Kieff Akira Kikuchi Chul-Woo Kim Kyu-Won Kim Seong-Jin Kim Tomohiro Kinoshita Issay Kitabayashi Yukihiko Kitamura Chifumi Kitanaka Tohru Kiyono Shinae Kizaka-Kondoh Alexander Knuth Kimitoshi Kohno Ryo Kominami Mineo Kurokawa Michihiko Kuwano Kiyotaka Kuzushima Yoshihiko Maehara Taira Maekawa Akira Matsuda Michiyuki Matsuda Yasuhiro Matsumura Masao Matsuoka Yoshio Miki Hironobu Minami Kinuko Mitani Tetsuya Mitsudomi Kiyoshi Miyagawa Eijii Miyoshi Morito Monden Masaki Mori Eiichi Morii Yoshinori Murakami Mikihiko Naito Yusaku Nakabeppu Kei Nakachi Hidewaki Nakagawa Kazuhiko Nakagawa Akira Nakagawara Shigeo Nakamura Takuro Nakamura Eiichi Nakayama Toshinori Nakayama Yoshiro Niitsu Toshiro Niki Takashi Nishimura Yasuharu Nishimura Kazuto Nishio Tetsuo Noda Masayuki Noguchi Shinzaburo Noguchi Atsushi Ochiai Katsuhiro Ogawa Yuichiro Ohe Hiroko Ohgaki Hiroshi Ohshima Atsushi Ohtsu Futoshi Okada Yasunori Okada Koji Ono Hiroyuki Osada Masanobu Oshima Mototsugu Oya Keiya Ozawa Pier Paolo Pandolfi Jae-Gahb Park Manuel Perucho Roger Reddel Nagahiro Saijo Ryuichi Sakai Toshiyuki Sakai Michiie Sakamoto Jacques Samarut Yasutsuna Sasaki Hironobu Sasano Noriyuki Sato Yasufumi Sato Hideyuki Saya Motoharu Seiki Hiroyuki Seimiya Yoshitaka Sekido Manuel Serrano Masao Seto Tatsuhiro Shibata Masabumi Shibuya Hiroshi Shiku Kunitada Shimotohno Hai-Rim Shin Tomoyuki Shirai Hiroki Shirato Robert H. Shoemaker Rashmi Sinha Tomotaka Sobue Eric Stanbridge Ih-Jen Su Yoshikazu Sugimoto Haruhiko Sugimura Akira Suzuki Kazuo Tajima Satoru Takahashi Takashi Takahashi Yoshimi Takai Nobuyuki Takakura Takuji Tanaka Yusuke Tanigawara Masaru Taniguchi Tadatsugu Taniguchi Masae Tatematsu Snorri S. Thorgeirsson Tomoki Todo Junya Toguchida Masakazu Toi Takashi Tokino Yutaka Tokuda Akihiro Tomida Shinya Toyokuni Hitoshi Tsuda Shoichiro Tsugane Masazumi Tsuneyoshi Tatsuhiko Tsunoda Heiichiro Udono Kazumitsu Ueda Yoshimasa Uehara Kazuo Umezawa Toshikazu Ushijima Keiji Wakabayashi Toshihiko Wakabayashi Paul Workman Hideo Yagita Tesshi Yamada Yasushi Yamazoe Takao Yamori Seiji Yano Wataru Yasui Masaki Yasukawa Yasushi Yatabe Jun Yokota Minoru Yoshida Teruhiko Yoshida Hiroyuki Yoshikawa Akihiko Yoshimura Tadashi Yoshino Yasuhito Yuasa Stuart H. Yuspa Secretaries for Editor-in-Chief Yataro Daigo | Ryuji Hamamoto For submission instructions and all other information visit http://wileyonlinelibrary.com/journal/cas This journal is available online at Wiley Online Library. Visit http://wileyonlinelibrary.com/journal/cas to search the articles and register for table of contents email alerts. Cover of this issue. S-222611, an oral reversible tyrosine kinase inhibitor of EGFR and HER2. A representative histological image of the colon treated with S-222611 (25 mg/kg). See also Tanaka, H., et al. (pages 1040–1048 of this issue). Cancer Science (formerly Japanese Journal of Cancer Research) is the official journal of the Japanese Cancer Association, and is published monthly. The journal was founded in 1907 as Gann, meaning cancer, by the late Dr. Katsusaburo Yamagiwa, who first produced skin cancer in experimental animals by painting tar on their skin. Cancer Science publishes original articles, editorials, letters to the editor, and reports describing original research in the fields of basic, translational and clinical cancer research. The following subject categories are covered: basic and clinical immunology, carcinogenesis, cell, molecular, and stem cell biology, clinical research, drug discovery and delivery, epidemiology and prevention, genetics, genomics, and proteomics, inflammation and virology, and pathology. The Journal also publishes review articles which may be solicited or submitted. Cancer Science is now part of the Wiley Open Access publishing program of fully open access journals published by Wiley. For further information visit the Wiley Open Access website at http://www.wileyopenaccess.com. JCA Board of Directors 2014: President: Tetsuo Noda Vice Presidents: Kohei Miyazono, Yoshio Miki, Masaki Mori Board: Okio Hino, Johji Inazawa, Fuyuki Ishikawa, Atsushi Ochiai, Hideyuki Saya, Takuro Nakamura, Tomoki Naoe, Yasuharu Nishimura, Atsushi Ohtsu, Masao Seto, Takashi Takahashi, Yasuhiro Matsumura, Yoshinori Murakami, Wataru Yasui President 2014 Annual Meeting Tetsuo Noda President 2015 Annual Meeting Tomoki Naoe Auditors: Takeshi Imamura, Hiroyuki Mano Secretary: Fukiko Shimada, Miho Hirai, Rie Yamaguchi, Satomi Onose Disclaimer: The Publisher, The Japanese Cancer Association and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this journal; the views and opinions expressed do not necessarily reflect those of the Publisher, The Japanese Cancer Association and Editors, neither does the publication of advertisements constitute any endorsement by the Publisher, The Japanese Cancer Association and Editors of the products advertised. Address for Editorial Correspondence: Cancer Science Editorial Office c/o Wiley Japan Frontier Koishikawa Building, 4F, 1-28-1 Koishikawa, Bunkyo-ku, Tokyo 112-0002, Japan E-mail: [e-mail] Tel: [phone] Fax: [phone] Address for Membership Queries: The Japanese Cancer Association c/o International Medical Information Center Shinanomachi Rengakan 35 Shinanomachi, Shinjuku-ku, Tokyo 160-0016, Japan E-mail: [e-mail] Tel: [phone] Fax: [phone] © 2014 (Japanese Cancer Association). The Japanese Cancer Association thanks Foundation of Japan Cancer Society for the financial help. Cancer Science is also supported in part by a Grant-in-Aid for Publication of Scientific Research Results from the Japan Society for the Promotion of Science (JSPS), Japan. ISSN 1349-7006 (Online) PUBLISHER Cancer Science is published by Wiley Publishing Asia Pty Ltd 155 Cremorne Street Richmond, Victoria 3121 Australia Tel: [phone] Fax: [phone] Production Editor Carissa Kwok (email: [e-mail]) Abstracting and Indexing Services The Journal is indexed by AgBiotech News & Information (CABI), BIOBASE: Current Awareness in Biological Sciences (Elsevier), Biological Abstracts (Thomson Reuters), BIOSIS Previews (Thomson Reuters), CAS: Chemical Abstracts Service (ACS), CSA Biological Sciences Database (ProQuest), CSA Oncogenes & Growth Factors Abstracts (ProQuest), Current Contents: Clinical Medicine (Thomson Reuters), Embase (Elsevier), HEED: Health Economic Evaluations Database (Wiley-Blackwell), Index Medicus/MEDLINE (NLM), InfoTrac, Journal Citation Reports/ Science Edition (Thomson Reuters), MEDLINE (NLM), PubMed Dietary Supplement Subset (NLM), Science Citation Index (Thomson Reuters), Science Citation Index Expanded (Thomson Reuters), SCOPUS (Elsevier). 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