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      Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock.

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          Abstract

          To evaluate (1) levels of the host-defense/antimicrobial peptide LL-37 in patients with trauma and hemorrhagic shock (HS) and (2) the effects of a synthetic host-defense peptide; Pep19-4LF on multiple organ failure (MOF) associated with HS.

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          Author and article information

          Journal
          Ann. Surg.
          Annals of surgery
          Ovid Technologies (Wolters Kluwer Health)
          1528-1140
          0003-4932
          Mar 10 2017
          Affiliations
          [1 ] *William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom †Department of Intensive Care and Intermediate Care, University Hospital RWTH Aachen, Aachen, Germany ‡Department of Drug Science and Technology, University of Turin, Turin, Italy §Barts Centre for Trauma Sciences, Blizard Institute, Queen Mary University of London, London, United Kingdom ¶Division of Biophysics, Forschungszentrum Borstel, Borstel, Germany ||Department of Anaesthesia and Intensive Care, University of Rostock, Rostock, Germany.
          Article
          10.1097/SLA.0000000000002186
          28288070
          97dd5153-323a-4b35-a676-3a8139c7a395
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