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      Reciprocal regulation between resting microglial dynamics and neuronal activity in vivo.

      1 , , , ,
      Developmental cell
      Elsevier BV

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          Abstract

          Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding neurons are still unclear. Using in vivo time-lapse imaging of both microglial morphology and neuronal activity in the optic tectum of larval zebrafish, we found that neuronal activity steers resting microglial processes and facilitates their contact with highly active neurons. This process requires the activation of pannexin-1 hemichannels on neurons. Reciprocally, such resting microglia-neuron contact reduces both spontaneous and visually evoked activities of contacted neurons. Our findings reveal an instructive role for neuronal activity in resting microglial motility and suggest the function for microglia in homeostatic regulation of neuronal activity in the healthy brain.

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          Author and article information

          Journal
          Dev Cell
          Developmental cell
          Elsevier BV
          1878-1551
          1534-5807
          Dec 11 2012
          : 23
          : 6
          Affiliations
          [1 ] Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.
          Article
          S1534-5807(12)00490-X
          10.1016/j.devcel.2012.10.027
          23201120
          97e3c37a-b86a-4d28-8494-8286be479e94
          Copyright © 2012 Elsevier Inc. All rights reserved.

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