Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
21
August
2015
Publication date Collection: 2015
Volume: 10
Issue: 8
Electronic Location Identifier: e0135678
Affiliations
[1
]Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294,
United States of America
[2
]Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294,
United States of America
[3
]Department of Biostatistics, The University of Alabama at Birmingham, Birmingham,
AL 35294, United States of America
[4
]Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL 35294,
United States of America
[5
]Department of Cell, Developmental and Integrative Biology, The University of Alabama
at Birmingham, Birmingham, AL 35294, United States of America
[6
]Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center,
Cincinnati, OH 35229, United States of America
[7
]Department of Veterans Affairs Medical Center, Birmingham, AL 35233, United States
of America
[8
]Center for Translational Science, Children's National Health System, Washington, DC
20010, United States of America
University of Iowa, UNITED STATES
Author notes
Competing Interests: The authors have read the journal's policy and the authors of this manuscript have
the following competing interests: M. M. received research support from Otsuka Pharmaceuticals
and Genzyme. L.G-W. is a consultant to Otsuka Pharmaceuticals. There are no patents,
products in development or marketed products to declare. This does not alter the authors'
adherence to all the PLOS ONE policies on sharing data and materials.
Conceived and designed the experiments: MM BJA XC LMG-W. Performed the experiments:
MM JZ CY. Analyzed the data: MM JZ CY BJA XC TRS GPS LMG-W. Wrote the paper: MM TRS
GPS BKY LMG-W. Interpreted the results of experiments: MM BJA GPS BKY LMG-W. Prepared
the figures: MM JZ CY. Drafted the manuscript: MM. Edited and revised manuscript:
BJA BKY LMGW. Approved final version of manuscript: MM JZ CY BJA XC TRS GPS BKY LMG-W.
Article
Publisher ID:
PONE-D-14-25269
DOI: 10.1371/journal.pone.0135678
PMC ID: 4546649
PubMed ID: 26295839
SO-VID: 97e57103-48d1-44c6-9711-5a3f006cfcaf
Copyright statement:
Copyright @
2015
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited
This work was supported by the American Heart Association National Scientist Development
Award 0535335N (M.M.) and by the Burroughs Wellcome Fund Clinical Scientific Award
in Translational Research (L.G-W). In addition, X.C. was in part supported by the
National Institutes of Health funded UAB-UCSD O’Brien Center 1P30 DK079337 and M.M.
by DK097423, by BX002985 from the Office of Research and Development, Medical Research
Service, Department of Veterans Affairs, and by the Detraz Endowed Research Fund in
Polycystic Kidney Disease. The presented study also utilized services provided by
Core A and Core D of the National Institutes of Health funded UAB Hepatorenal Fibrocystic
Disease Core Center P30-DK-074038. Finally, a subset of experimental crosses was generated
by Core 3 (Gnotobiotic and Genetically-Engineered Mouse Core) of the National Institutes
of Health funded Mucosal HIV and Immunobiology Center P30 DK064400. The funders had
no role in study design, data collection and analysis, decision to publish, or preparation
of the manuscript.