+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Systemic and Renal Hemodynamic Effects of Dopamine and Prostaglandin A alone and in Combination

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          Prostaglandin A (PGA) compounds infused intravenously at rates of 0.125, 0.25 and 0.50 µg/kg/min decreased mean aortic pressure and renal vascular resistance, but did not increase renal blood flow in pentobarbital-anesthetized dogs. In contrast, dopamine increased renal blood flow at infusion rates of 2.5, 5.0 and 7.5 µg/kg/min and increased mean aortic pressure at infusion rates of 5.0 and 7.5 µg/kg/min. With simultaneous infusions of PGA (0.125 and 0.25 µg/kg/min) and dopamine (2.5, 5.0 and 7.5 µg/kg/min), mean aortic pressure decreased and renal blood flow increased. In open-chest dogs, cardiac contractile force was increased more by dopamine than by PGA. Neither agent alone altered heart rate, but when administered together, heart rate increased. PGA (0.01–0.02 µg/kg/min) abolished the increase in blood pressure produced by larger doses of dopamine (15–20 µg/kg/min) without reducing the increase in renal blood flow. Thus, by varying infusion rates of dopamine and PGA, renal blood flow may be increased with no change, an increase or a decrease in arterial pressure.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 11
          : 1-2
          : 86-95
          Clinical Pharmacology Program, Emory University School of Medicine, Atlanta, Ga.
          158002 Blood Vessels 1974;11:86–95
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Research Paper


          Comment on this article