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      The notch pathway is activated in neoplastic progression in esophageal squamous cell carcinoma.

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          Abstract

          The Notch signaling pathway is integral to normal human development and homeostasis and has a deterministic function on cell differentiation. Recent studies suggest aberrant Notch signaling may contribute to neoplastic progression by an increase in stem cell survival, chemoresistance, and the promotion of epithelial-to-mesenchymal transition. The goals of our study were to determine, utilizing quantitative technologies, the expression of activated Notch 1 in esophageal squamous cell carcinoma (SCC) and to determine the relationship between Notch 1 expression and various clinicopathologic parameters. Immunohistochemical staining for Notch intracellular domain (NICD) was performed on 60 consecutive cases of esophageal squamous cell carcinoma, 42 cases of benign esophageal squamous epithelium, and 13 cases of eosinophilic esophagitis diagnosed in our department from 2007 through 2015, and exact nuclear staining and nuclear characteristics were graded using the Vectra imaging system. Clinicopathologic data (gender, age at diagnosis, smoking status, tumor grade, tumor stage, tumor location, and survival) were collected for each SCC case and these were correlated with NICD staining. Cases of esophageal SCC demonstrated significantly higher NICD staining compared to cases of benign and reactive esophageal epithelium (P=.003 and .005, respectively). Among cases of esophageal SCC, nuclear NICD staining was significantly correlated with both tumor grade and stage. Following classification and regression tree analysis, esophageal SCC patients with increased NICD expression were found to be more likely to die from their disease than those with lower levels of expression. Taken together, the findings suggest that increased Notch 1 may contribute to the development and aggressiveness of esophageal SCC.

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          Author and article information

          Journal
          Hum. Pathol.
          Human pathology
          Elsevier BV
          1532-8392
          0046-8177
          Feb 2018
          : 72
          Affiliations
          [1 ] Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104. Electronic address: Daniel.Lubin@uphs.upenn.edu.
          [2 ] Department of Biostatistics and Epidemiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, 19104.
          [3 ] Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, 19104.
          Article
          S0046-8177(17)30411-2
          10.1016/j.humpath.2017.11.004
          29137934
          97ed5279-743a-4b15-a0dc-b9139e992de8
          History

          Surgical pathology,Esophageal squamous cell carcinoma,Notch signaling,Overall survival,Carcinogenesis

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