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      Endogenous kynurenines as targets for drug discovery and development.

        1 ,
      Nature reviews. Drug discovery
      Springer Science and Business Media LLC

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          Abstract

          The kynurenine pathway is the main pathway for tryptophan metabolism. It generates compounds that can modulate activity at glutamate receptors and possibly nicotinic receptors, in addition to some as-yet-unidentified sites. The pathway is in a unique position to regulate other aspects of the metabolism of tryptophan to neuroactive compounds, and also seems to be a key factor in the communication between the nervous and immune systems. It also has potentially important roles in the regulation of cell proliferation and tissue function in the periphery. As a result, the pathway presents a multitude of potential sites for drug discovery in neuroscience, oncology and visceral pathology.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1776
          1474-1776
          Aug 2002
          : 1
          : 8
          Affiliations
          [1 ] Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK. T.W.Stone@bio.gla.ac.uk
          Article
          10.1038/nrd870
          12402501
          980208ae-ce09-4d62-8f65-b2283b90ed77

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