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      I-E-independent deletion of V beta 17a+ T cells by Mtv-3 from the nonobese diabetic mouse.

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          Abstract

          Analysis of TCR beta-chain V region (V beta) frequency among NOD lymphocytes reveals a profound depletion of V beta 3+ T cells, and a recent study has linked this phenomenon to the Mtv-3 insertion on chromosome 11. When the V beta 17a gene segment is introduced into mice with an nonobese diabetic mouse background, T cells bearing the TCR encoded by this gene segment are also dramatically reduced in frequency. Deletion of V beta 17a+ T cells segregates with deletion of T cells bearing V beta 3 and occurs in the absence of I-E, which had been shown in previous studies to be a major deleting element for V beta 17a+ thymocytes.

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          Author and article information

          Journal
          J. Immunol.
          Journal of immunology (Baltimore, Md. : 1950)
          0022-1767
          0022-1767
          Apr 01 1992
          : 148
          : 7
          Affiliations
          [1 ] Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver 80262.
          Article
          1531997
          980224d1-7e4e-4521-852a-78b1c7c9251b

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