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      A Metabolic Roadblock in Inflammatory Macrophages.

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      Cell reports

      Elsevier BV

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          Abstract

          In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more homeostatic M2 macrophage.

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          Author and article information

          Journal
          Cell Rep
          Cell reports
          Elsevier BV
          2211-1247
          Oct 11 2016
          : 17
          : 3
          Affiliations
          [1 ] School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin 2, Ireland. Electronic address: laoneill@tcd.ie.
          Article
          S2211-1247(16)31361-4
          10.1016/j.celrep.2016.09.085
          27732839

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