Renal Clearance of Amino Acids in Patients with Severe Chronic Renal Failure

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Abstract

The renal clearance of 21 amino acids was investigated in 5 patients with chronic renal failure (inulin clearance ≈ 5–10ml/min) during the 6-week administration of a low-protein diet. The results were compared with values obtained in 6 volunteers. The renal clearance of all investigated amino acids (with the exception of Asp, His, Tau) did not differ significantly from healthy controls. The excretion fraction (amino acid clearance /inulin clearance 100) was in all investigated amino acids significantly higher than incontrols with the exception of Tau. The excretion fractions of Asp, Ser, Cys, Tyr, His, Thr, Tau and Gly were, on average, above 20%.The findings suggest that the fractional reabsorption of amino acids in residual nephrons is decreased.

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Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 02 December 2008

Volume: 20

Issue: 2

Pages: 83-89

Affiliations

3rd Research Unit of Internal Medicine, Institute for Clinical and Experimental Medicine, Prague

Article

Publisher ID: 181199 Other ID: Nephron 1978;20:83–89

DOI: 10.1159/000181199

PubMed ID: 622213

SO-VID: 9804ad24-5c97-42cf-ab13-fd7c05f1e9fb

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 12 October 1976

Date accepted : 25 April 1977

Page count

Pages: 7

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