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      Erratum: Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans

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      microPublication Biology
      Caltech Library

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          Abstract

          Description Cohen, SM; Sun, JJ; Schroeder, FC; Sternberg, PW (2021). Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans. microPublication Biology. 10.17912/micropub.biology.000397. Erratum in: microPublication Biology. 10.17912/micropub.biology.000466. The links to extended data files were omitted from the original article, this has been corrected. Links to the extended data files Cohen2021_N2_Ascr_extended and Cohen2021_daf-22_Ascr_extended have been attached to the original article.

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          Transcriptional Response to a Dauer-Inducing Ascaroside Cocktail in Late L1 in C. elegans

          The dauer diapause stage in C. elegans is a non-feeding alternative to the L3 larval stage that is highly resistant to harsh environmental conditions. The decision to enter dauer is a two-step process. First, L1 larvae encounter adverse conditions such as lack of food or overcrowding and decide to enter the L2d rather than the L2 stage. Second, L2d worms that continue to experience disadvantageous conditions decide to enter dauer instead of L3. Here, we have used RNA-seq to characterize the transcriptional response to a cocktail of dauer-inducing ascaroside pheromones at the late L1 stage as worms enter the L2d phase. We find that, in response to ascarosides, C. elegans L1 larvae preparing to enter the L2d stage begin upregulating genes involved in stress response and downregulating genes associated with growth and metabolism.
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            Author and article information

            Journal
            MicroPubl Biol
            MicroPubl Biol
            microPublication Biology
            Caltech Library
            2578-9430
            10 September 2021
            2021
            10 September 2021
            : 2021
            : 10.17912/micropub.biology.000466
            Article
            10.17912/micropub.biology.000466
            8438583
            98068a3e-7355-4311-9927-94df8fc30d13
            Copyright: © 2021 by the authors

            This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

            History
            : 10 September 2021
            : 10 September 2021
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            Erratum

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