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      Calcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgaris

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          Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 μg/g plus betamethasone dipropionate 0.5 mg/g (Dovobet ®, Daivobet ®, Taclonex ®), which combines a vitamin D analog and a corticosteroid. This innovative formulation preserves the activity and bioavailability of the two components and many clinical studies have demonstrated that it has a greater efficacy, tolerability, and a rapid onset of action compared with its individual ingredients or tacalcitol.

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          Most cited references 61

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          Gene regulation by steroid hormones.

           Miguel Beato (1989)
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            Psoriasis--epidemiology and clinical spectrum.

            Despite psoriasis being a common skin disease, there are still a number of unanswered questions. One of these is the prevalence of the disease, as there is a lack of specific data, with the majority of studies reporting estimates only. Population based studies are rare and longitudinal observations on changing prevalence rates are lacking. This contrasts with other T-cell mediated autoimmune diseases where the number of those affected is rising. Epidemiological studies revealed that a distinct group of diseases is quite frequently associated with psoriasis, e.g. arthritis, colitis, diabetes and hypertension. In contrast, atopic dermatitis and allergies are less frequently seen compared to normal rates of occurrence. As the psoriatic immune response pattern relates to activated Th-1 cells, psoriasis and atopic dermatitis appear to be mutually exclusive due to the Th-1/Th-2 dichotomy.
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              Recent breakthroughs in the treatment of psoriasis have led to improved understanding of the pathogenesis of this disease. Activation of T lymphocytes leading to release of cytokines results in proliferation of keratinocytes. Several new biological therapies have been developed, which target specific steps in the pathogenesis of psoriasis. With these new treatments, variable degrees of clearing occur. Initial data suggest improved safety over older agents such as methotrexate and ciclosporin, but long-term data are necessary. Enhancements in topical therapy and phototherapy have also increased the armamentarium of treatments available for this disorder.

                Author and article information

                Ther Clin Risk Manag
                Therapeutics and Clinical Risk Management
                Therapeutics and Clinical Risk Management
                Dove Medical Press
                February 2008
                February 2008
                : 4
                : 1
                : 141-148
                A’ Department of Dermatology, Aristotle University of Thessaloniki Greece
                Author notes
                Correspondence: Efstratios Vakirlis A’ Department of Dermatology, Aristotle University of Thessaloniki, 13, Kanari str, 54644 Thessaloniki, Greece Tel +3023 1027 7078 Fax +3023 1023 3171 Email stratos@ 123456med.auth.gr
                © 2008 Dove Medical Press Limited. All rights reserved


                dovobet, daivobet, psoriasis, calcipotriol/betamethasone dipropionate, taclonex


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