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      Growth Hormone Dependency of the Effect of Human Serum on Thymidine Uptake by Lectin-Activated Human Lymphocytes

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          This study of the effect of serum dialysis on thymidine incorporation into lectin-activated blood lymphocytes cultured in vitro showed that (1) after serum dialysis <sup>3</sup>H-thymidine incorporation is very low or absent; (2) the addition of L-glutamine to dialyzed sera leads to recovery of 18% of <sup>3</sup>H-thymidine uptake, and (3) addition of L-glutamine reduces the difference in the stimulating effects of acromegalic and hypopituitary sera observed before dialysis in a medium free of L-glutamine. Since the plasma level of glutamine is increased in acromegalics and reduced in hypopituitary patients, it is suggested that this amino acid acts as a growth hormone dependent factor or cofactor in the regulation of cell growth.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          26 November 2008
          : 19
          : 1
          : 5-11
          Laboratoire de Recherche sur la Croissance (Inserm U-188), Paris, France
          179853 Horm Res 1984;19:5–11
          © 1984 S. Karger AG, Basel

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          Pages: 7


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