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      Mechanisms of anemia in CKD.

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          Abstract

          Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These insights hold promise for the development of new diagnostic tests and therapies that directly target the pathophysiologic processes underlying this form of anemia.

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          Author and article information

          Journal
          J. Am. Soc. Nephrol.
          Journal of the American Society of Nephrology : JASN
          American Society of Nephrology (ASN)
          1533-3450
          1046-6673
          Oct 2012
          : 23
          : 10
          Affiliations
          [1 ] Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA. babitt.jodie@mgh.harvard.edu
          Article
          ASN.2011111078
          10.1681/ASN.2011111078
          3458456
          22935483
          982500eb-1725-45cb-8888-4b436887e3e6
          History

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