3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Brain imaging genetics in ADHD and beyond – mapping pathways from gene to disorder at different levels of complexity

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Attention-deficit/hyperactivity disorder (ADHD) is a common and often persistent neurodevelopmental disorder. Beyond gene-finding, neurobiological parameters, such as brain structure, connectivity, and function, have been used to link genetic variation to ADHD symptomatology. We performed a systematic review of brain imaging genetics studies involving 62 ADHD candidate genes in childhood and adult ADHD cohorts. Fifty-one eligible research articles described studies of 13 ADHD candidate genes. Almost exclusively, single genetic variants were studied, mostly focussing on dopamine-related genes. While promising results have been reported, imaging genetics studies are thus far hampered by methodological differences in study design and analysis methodology, as well as limited sample sizes. Beyond reviewing imaging genetics studies, we also discuss the need for complementary approaches at multiple levels of biological complexity and emphasize the importance of combining and integrating findings across levels for a better understanding of biological pathways from gene to disease. These may include multi-modal imaging genetics studies, bioinformatic analyses, and functional analyses of cell and animal models.

          Related collections

          Author and article information

          Journal
          7806090
          6166
          Neurosci Biobehav Rev
          Neurosci Biobehav Rev
          Neuroscience and biobehavioral reviews
          0149-7634
          1873-7528
          21 June 2019
          31 January 2017
          September 2017
          08 January 2020
          : 80
          : 115-155
          Affiliations
          [1 ]Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, The Netherlands
          [2 ]Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Nijmegen, The Netherlands
          [3 ]Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, The Netherlands
          Author notes
          [* ] CORRESPONDING AUTHOR: Prof. Dr. Barbara Franke, Postal address: Department of Human Genetics (855), Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands, barbara.franke@ 123456radboudumc.nl
          Article
          PMC6947924 PMC6947924 6947924 nihpa882132
          10.1016/j.neubiorev.2017.01.013
          6947924
          28159610
          9827edee-ea7b-4d05-a607-fecc42dfcc5f
          History
          Categories
          Article

          candidate genes,animal models,brain imaging genetics,endophenotype,ADHD

          Comments

          Comment on this article