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      Neurobiology of food intake in health and disease.

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          Abstract

          Under normal conditions, food intake and energy expenditure are balanced by a homeostatic system that maintains stability of body fat content over time. However, this homeostatic system can be overridden by the activation of 'emergency response circuits' that mediate feeding responses to emergent or stressful stimuli. Inhibition of these circuits is therefore permissive for normal energy homeostasis to occur, and their chronic activation can cause profound, even life-threatening, changes in body fat mass. This Review highlights how the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions.

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          Author and article information

          Journal
          Nat Rev Neurosci
          Nature reviews. Neuroscience
          Springer Science and Business Media LLC
          1471-0048
          1471-003X
          Jun 2014
          : 15
          : 6
          Affiliations
          [1 ] Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington 98109, USA.
          Article
          nrn3745 NIHMS598782
          10.1038/nrn3745
          4076116
          24840801
          982ba225-86e5-46c9-9687-6c549ded3808
          History

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