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      Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer

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      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 12 , 22 , 3 , 23 , 24 , 25 , 26 , 27 , 5 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 2 , 35 , 36 , 37 , 38 , 3 , 5 , 39 , 34 , 40 , 41 , 42 , 43 , 38 , 44 , 45 , 46 , 47 , 48 , 49 , 2 , 50
      Annals of Oncology
      Oxford University Press
      consensus conference, diagnosis, germ-cell cancer, late toxic effects, long-term follow-up, treatment

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          Abstract

          In November 2011, the Third European Consensus Conference on Diagnosis and Treatment of Germ-Cell Cancer (GCC) was held in Berlin, Germany. This third conference followed similar meetings in 2003 (Essen, Germany) and 2006 (Amsterdam, The Netherlands) [Schmoll H-J, Souchon R, Krege S et al. European consensus on diagnosis and treatment of germ-cell cancer: a report of the European Germ-Cell Cancer Consensus Group (EGCCCG). Ann Oncol 2004; 15: 1377–1399; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part I. Eur Urol 2008; 53: 478–496; Krege S, Beyer J, Souchon R et al. European consensus conference on diagnosis and treatment of germ-cell cancer: a report of the second meeting of the European Germ-Cell Cancer Consensus group (EGCCCG): part II. Eur Urol 2008; 53: 497–513]. A panel of 56 of 60 invited GCC experts from all across Europe discussed all aspects on diagnosis and treatment of GCC, with a particular focus on acute and late toxic effects as well as on survivorship issues.

          The panel consisted of oncologists, urologic surgeons, radiooncologists, pathologists and basic scientists, who are all actively involved in care of GCC patients. Panelists were chosen based on the publication activity in recent years. Before the meeting, panelists were asked to review the literature published since 2006 in 20 major areas concerning all aspects of diagnosis, treatment and follow-up of GCC patients, and to prepare an updated version of the previous recommendations to be discussed at the conference. In addition, ∼50 E-vote questions were drafted and presented at the conference to address the most controversial areas for a poll of expert opinions. Here, we present the main recommendations and controversies of this meeting. The votes of the panelists are added as online supplements.

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          Author and article information

          Journal
          Ann Oncol
          Ann. Oncol
          annonc
          annonc
          Annals of Oncology
          Oxford University Press
          0923-7534
          1569-8041
          April 2013
          14 November 2012
          14 November 2012
          : 24
          : 4
          : 878-888
          Affiliations
          [1 ]Department of Hematology and Oncology, Vivantes Klinikum Am Urban , Berlin
          [2 ]Department of Urology, University Hospital , Düsseldorf, Germany
          [3 ]Department of Medical Oncology, University Medical Center , Groningen, The Netherlands
          [4 ]Department of Medical Oncology, University Hospital La Fe , Valencia, Spain
          [5 ]Department of Medical Oncology, BMT and Pulmonology University Hospital , Hamburg
          [6 ]Department of Urology, Charite University Hospital , Berlin, Germany
          [7 ]Department of Internal Medicine, Kantonsspital Graubünden , Switzerland
          [8 ]Department of Oncology, University Hospital , Lund, Sweden
          [9 ]Department of Urology, The Christie Hospital , Manchester, UK
          [10 ]Department of Radiation Oncology, St. Vincentius Hospital , Karlsruhe, Germany
          [11 ]Department of Oncology, Karolinska Institute and University Hospital , Stockholm, Sweden
          [12 ]National Resource Center for Late Effects, Department of Onocology, The Norwegian Radium Hospital and University of Oslo , Oslo, Norway
          [13 ]Department of Oncology, Rigshospitalet, Copenhagen, Denmark
          [14 ]Department of Oncology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) , Meldola, Italy
          [15 ]3rd Medical Department, Kaiser-Franz-Josef-Spital, ACR-ITR VIEnna, LBI-ACR VIEnna , Vienna, Austria
          [16 ]Department of Hematology and Oncology, Vivantes Klinikum Neukölln , Berlin, Germany
          [17 ]Department of Medical Oncology, Erasmus University , Rotterdam, The Netherlands
          [18 ]Department of Urology, Albertinen Hospital , Hamburg
          [19 ]Department of Hematology and Oncology, Medizinische Hochschule , Hannover, Germany
          [20 ]Department of Medicine, Institute Gustave Roussy , Villejuif
          [21 ]Department of Medical Oncology, Centre Léon Bérard , Lyon, France
          [22 ]Department of Medical Oncology, IDIBELL, Institut Català d'Oncologia , Barcelona, Spain
          [23 ]Department of Oncology, Kantonsspital St. Gallen , St. Gallen, Switzerland
          [24 ]Reproductive Medicine Center, Skane University Hospital , Malmö, Sweden
          [25 ]Department of Medical Oncology, University Hospital Schleswig-Holstein , Kiel
          [26 ]Department of Urology, University Hospital , Aachen, Germany
          [27 ]Department of Hematology and Oncology, Harlaching Hospital , Munich, Germany
          [28 ]Department of Radiotherapy, The Royal Marsden Hospital , London
          [29 ]Department of Radiotherapy, Institute of Cancer Research, The Royal Marsden Hospital , London, UK
          [30 ]Center for Reproductive Medicine and Andrology, University Hospital , Münster, Germany
          [31 ]Division of Medical Oncology, University of British Columbia , Vancouver, Canada
          [32 ]Department of Urology, Hospital Maria Hilf , Krefeld, Germany
          [33 ]Department of Urology, Academic Medical Center, University of Amsterdam , Amsterdam
          [34 ]Department of Pathology, Erasmus Medical Center , Rotterdam, The Netherlands
          [35 ]Department of Clinical Oncology, Hopital Tenon , Paris, France
          [36 ]Department of Hematology and Oncology, University Hospital , Tübingen, Germany
          [37 ]Departments of Medical Oncology, Medical Oncology Unit 2
          [38 ]Departments of Surgery, Urology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori , Milan, Italy
          [39 ]Departments of Clinical Cancer Research , The Norwegian Radium Hospital , Oslo University Hospital , Oslo, Norway
          [40 ]Department of Medical Oncology, St. Bartholomews Hospital , London, UK
          [41 ]Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
          [42 ]Department of Medicine, Hospital Reinhardshöhe , Bad Wildungen, Germany
          [43 ]Department of Medical Oncology, Ospedale Civile Ca’ Foncello , Treviso, Italy
          [44 ]Department of Urology, University Hospital , Ulm
          [45 ]Gemeinschaftspraxis Pathologie, Starnberg, Germany
          [46 ]Department of Radiotherapy and Radiation Oncology, Paracelsus Medical University Hospital , Salzburg, Austria
          [47 ]Department of Diagnostic Radiology, The Royal Marsden Hospital , London, UK
          [48 ]Department of Radiation Oncology, University Hospital , Tübingen, Germany
          [49 ]Department of Oncology, St Olavs Hospital , Trondheim, Norway
          [50 ]Institute of Pathology, University Hospital , Leipzig, Germany
          Author notes
          [* ] Correspondence to: Prof Dr J. Beyer, Department of Hematology and Oncology, Vivantes Klinikum Am Urban, Dieffenbachstrasse 1, Berlin D-10967, Germany. Tel: +49-30-130-222 100; Fax: +49-30-130-222-105; E-mail: joerg.beyer@ 123456vivantes.de
          [†]

          Invited and involved in the preparation of the conference, but unable to attend.

          Article
          mds579
          10.1093/annonc/mds579
          3603440
          23152360
          983be66a-0bec-4a7f-a428-cd7f157dd577
          © The Author 2012. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

          This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

          History
          : 22 May 2012
          : 17 September 2012
          : 1 October 2012
          Categories
          Reviews

          Oncology & Radiotherapy
          consensus conference,diagnosis,germ-cell cancer,late toxic effects,long-term follow-up,treatment

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