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      Enhanced Volume-Sensitive K Flux in Patients on Chronic Hemodialysis

      , ,

      Nephron

      S. Karger AG

      Erythrocyte, K-Cl cotransport, Hemodialysis, 86Rb uptake

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          Abstract

          Swelling-activated K flux was investigated in erythrocytes from patients on regular hemodialysis. K influx, measured by <sup>86</sup>Rb uptake, was increased in hemodialysis patients from 25.5 ± 0.6 to 47.3 ± 3.4 nmol/10<sup>9</sup>cells/h (n = 4, p < 0.01), when the medium osmolarity of Hepes buffer was decreased by 100 mosm/kg H<sub>2</sub>0. In normal subjects, K influx was also stimulated from 28.1 ± 1.2 to 37.8 ± 2.1 nmol/l0<sup>9</sup>cells/h (n = 4, p < 0.01). The swelling-activated increment of K influx was comparatively higher in hemodialysis patients (85.5 vs. 34.5% in controls). Reduction of the medium osmolarity by 100 mosm/kg H<sub>2</sub>O also caused a larger increase of K efflux in hemodialysis patients than in control subjects (171.1 vs. 118.1%). K efflux was increased even in the presence of 10<sup>-4</sup> M ouabain (from 284 ± 25 to 879 ± 122 nmol/10<sup>9</sup>cells/h), although the increment of K efflux was completely abolished when Cl was replaced by gluconate (555 ± 47 nmol/10<sup>9</sup>cells/h with Cl and 467 ± 44 nmol/10<sup>9</sup>cells/h without Cl). These data suggest that in hemodialysis patients, swelling-activated K transport is enhanced via activation of the Cl-dependent ouabain-insensitive K transport pathway.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1994
          1994
          17 December 2008
          : 68
          : 1
          : 71-76
          Affiliations
          Division of Nephrology, Department of Medicine, Jichi Medical School, Tochigi, Japan
          Article
          188222 Nephron 1994;68:71–76
          10.1159/000188222
          7991043
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Erythrocyte, K-Cl cotransport, Hemodialysis, 86Rb uptake

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