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      Reducing intrusive traumatic memories after emergency caesarean section: A proof-of-principle randomized controlled study

      research-article
      , D.Clin.Psych. a , b , , , MD a , , M.Sc. a , , MD c , , D.Clin.Psych. d , , Ph.D. e , , Ph.D. f , , Ph.D. g , , Ph.D. h
      Behaviour Research and Therapy
      Elsevier Science
      Posttraumatic stress disorder, Acute stress disorder, Early intervention, Proof-of-principle randomized controlled study, Cognitive, Computerized, Childbirth, Universal intervention, ECS, emergency caesarean section, PTSD, posttraumatic stress disorder, ASD, acute stress disorder, ASDS, Acute Stress Disorder Scale, HADS, Hospital Anxiety and Depression Scale, PDS, Posttraumatic Diagnostic Scale

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          Abstract

          Preventative psychological interventions to aid women after traumatic childbirth are needed. This proof-of-principle randomized controlled study evaluated whether the number of intrusive traumatic memories mothers experience after emergency caesarean section (ECS) could be reduced by a brief cognitive intervention. 56 women after ECS were randomized to one of two parallel groups in a 1:1 ratio: intervention (usual care plus cognitive task procedure) or control (usual care). The intervention group engaged in a visuospatial task (computer-game ‘Tetris’ via a handheld gaming device) for 15 min within six hours following their ECS. The primary outcome was the number of intrusive traumatic memories related to the ECS recorded in a diary for the week post-ECS. As predicted, compared with controls, the intervention group reported fewer intrusive traumatic memories ( M = 4.77, SD = 10.71 vs. M = 9.22, SD = 10.69, d = 0.647 [95% CI: 0.106, 1.182]) over 1 week (intention-to-treat analyses, primary outcome). There was a trend towards reduced acute stress re-experiencing symptoms ( d = 0.503 [95% CI: −0.032, 1.033]) after 1 week (intention-to-treat analyses). Times series analysis on daily intrusions data confirmed the predicted difference between groups. 72% of women rated the intervention “rather” to “extremely” acceptable. This represents a first step in the development of an early (and potentially universal) intervention to prevent postnatal posttraumatic stress symptoms that may benefit both mother and child.

          Clinical trial registration

          ClinicalTrials.gov, www.clinicaltrials.gov, NCT02502513.

          Highlights

          • An intervention to reduce traumatic memories in mothers after ECS was tested.

          • We compared usual care plus visuospatial cognitive task with usual care.

          • After 1 week, the intervention group reported fewer intrusive traumatic memories.

          • They also showed a trend towards reduced acute stress re-experiencing symptoms after 1 week.

          • This early game-based computerized intervention may benefit both mother and child.

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          Most cited references41

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          The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.
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            Rank Transformations as a Bridge Between Parametric and Nonparametric Statistics

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              Psychological theories of posttraumatic stress disorder.

              We summarize recent research on the psychological processes implicated in posttraumatic stress disorder (PTSD) as an aid to evaluating theoretical models of the disorder. After describing a number of early approaches, including social-cognitive, conditioning, information-processing, and anxious apprehension models of PTSD, the article provides a comparative analysis and evaluation of three recent theories: Foa and Rothbaum's [Foa, E. B. & Rothbaum, B. O. (1998). Treating the trauma of rape: cognitive behavioral therapy for PTSD. New York: Guilford Press] emotional processing theory; Brewin, Dalgleish, and Joseph's [Psychological Review 103 (1996) 670] dual representation theory; Ehlers and Clark's [Behaviour Research and Therapy 38 (2000) 319] cognitive theory. We review empirical evidence relevant to each model and identify promising areas for further research.
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                Author and article information

                Contributors
                Journal
                Behav Res Ther
                Behav Res Ther
                Behaviour Research and Therapy
                Elsevier Science
                0005-7967
                1873-622X
                1 July 2017
                July 2017
                : 94
                : 36-47
                Affiliations
                [a ]Department Woman-Mother-Child, University Hospital Lausanne, Lausanne, Switzerland
                [b ]Department of Endocrinology, Diabetes, and Metabolism, University Hospital Lausanne, Lausanne, Switzerland
                [c ]Department of Child and Adolescent Psychiatry, University Hospital Lausanne, Lausanne, Switzerland
                [d ]Mental Health Research and Treatment Center, Ruhr-Universität Bochum, Bochum, Germany
                [e ]Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
                [f ]Department of Psychiatry, University of Oxford, Oxford, UK
                [g ]Department of Zoology, University of Oxford, Oxford, UK
                [h ]Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
                Author notes
                []Corresponding author. Unité de Développement CHUV, Maternité, Avenue Pierre-Decker 2, 1011 Lausanne, Switzerland.Unité de Développement, MaternitéAvenue Pierre-Decker 2Lausanne1011Switzerland antje.horsch@ 123456chuv.ch
                Article
                S0005-7967(17)30067-0
                10.1016/j.brat.2017.03.018
                5466064
                28453969
                9841ddd4-108d-4244-a7be-e0e797531c1b
                © 2017 The Authors

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                : 3 October 2016
                : 2 February 2017
                : 28 March 2017
                Categories
                Article

                Clinical Psychology & Psychiatry
                posttraumatic stress disorder,acute stress disorder,early intervention,proof-of-principle randomized controlled study,cognitive,computerized,childbirth,universal intervention,ecs, emergency caesarean section,ptsd, posttraumatic stress disorder,asd, acute stress disorder,asds, acute stress disorder scale,hads, hospital anxiety and depression scale,pds, posttraumatic diagnostic scale

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